Results 91 to 100 of about 3,079,778 (336)

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Appropriate treatment for nail breakage following femur intertrochanteric fractures without additional reduction: case series and literature review

BMC Musculoskeletal Disorders
Background Intramedullary nail breakage is an uncommon complication in patients with femoral intertrochanteric fractures treated with proximal femoral nail antirotation.
Hong Man Cho, Haeryong Heo, Myung Cheol Jung, Woochull Chung, Eunho Choi, Young Lee, Yoon Suh Cho   +6 more
doaj   +1 more source

Flexible intramedullary nailing in the treatment of diaphyseal fractures of the femur in preschool children [PDF]

, 2008
Femur fractures in preschool children are mostly treated in a conservative way, by means of spica cast immobilisation or skin traction. In school age children the use of flexible intramedullary nails (FIN) is widely used and promoted.
De Ridder, Koen, MORTIER, DIETER
core   +1 more source

Closure of the nasal cavities in the treatment of refractory hereditary haemorrhagic telangiectasia [PDF]

, 1997
From a cohort of 35 patients with hereditary haemorrhagic telangiectasia (HHT), 12 patients have undergone closure of the one or both nasal cavities during the last three years for refractory epistaxis.
Howard, DJ, Lund, VJ
core   +1 more source

Elastomeric Micro‐Balloons for Remote Control of Cerebral Blood Flow and Real‐Time In vivo Imaging of Rodent Brain Response to Hypoperfusion

Advanced Materials, EarlyView.
This study reports the fabrication of MRI‐compatible elastomeric micro‐balloons via a multi‐step bubble casting process, where the monolithic elastomeric wall is selectively stiffened for reversible and controlled inflation and elasticity, depending on the target vessels for graded occlusion of cerebral arteries.
Jong Bin Kim, Jinghui Wang, Yinding Chi, Jingxian Wu, Alicia Ng, Guanda Qiao, Honglin Tan, Miroslaw Janowski, Piotr Walczak, Yajie Liang, Shu Yang   +10 more
wiley   +1 more source

Transverse V-Y advancement composite tissue flap for repairing defects after longitudinal melanonychia excision—a retrospective cohort study

Frontiers in Surgery
Longitudinal melanonychia (LM) is a common nail disorder that sometimes requires surgical excision to rule out malignancy. However, longitudinal complete removal of LM, as one type of method for some special patient, can leave a significant defect in the
Jianhua Zhang, Zhenjun Xie, Wei Su
doaj   +1 more source

Intracranial fusarium fungal abscess in an immunocompetent patient: case report and review of the literature. [PDF]

, 2014
Introduction Fusarium spp is an omnipresent fungal species that may lead to fatal infections in immunocompromised populations. Spontaneous intracranial infection by Fusarium spp in immunocompetent individuals is exceedingly rare.
Cadden, Joseph, Commins, Deborah, Giannotta, Steven L, Lee, Brian, Peterson, Asa, Pham, Martin H, Zada, Gabriel   +6 more
core   +1 more source

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source

Update on surgical management of onychocryptosis

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022
Onychocryptosis is an inflammatory disease of the lateral nail fold resulting from the embedding of the lateral border of the nail plate in the periungual soft tissues with consequential formation of granulation tissue and hypertrophy of the lateral nail
Duarte Flor, Ricardo Vieira
doaj