Results 301 to 310 of about 415,928 (403)

Terry's Nails Without Systemic Disease: A Case Report of a Unique Clinical Sign. [PDF]

Cureus
Aldairi AS, Alsaedi F, Beheiry DH, Hakim M, Allihibi I, Alotaibi H.   +5 more
europepmc   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Poikiloderma with neutropenia, Clericuzio-type: Case report of a 7-year-old Syrian child. [PDF]

Medicine (Baltimore)
Alabed A, Al Haj Kadour M, Alshaar N, Alloush A, Khalil B.   +4 more
europepmc   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

Onychorrhexis and onychoschizia associated with ibrutinib therapy. [PDF]

JAAD Case Rep
Baroz AR, Buist R, Mervak JE.
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

3-year revision rates of left vs right cephalomedullary nails with a helical blade design. [PDF]

Ir J Med Sci
Kelly L, Moloney D, Collins D.
europepmc   +1 more source

Healing smarter: A systematic review and meta-analysis of bioresorbable implants for paediatric forearm fractures. [PDF]

J Child Orthop
Eastwood F, Raheman F, Al-Dairy G, Popescu M, Henney C, Hunwick L, Buddhdev P.   +6 more
europepmc   +1 more source

Letter to the Editor: elevating fingernail hygiene in parasitic disease prevention - implications from Hajipour and Valizadeh's study. [PDF]

IJID Reg
Rattanapitoon NK, Thanchonnang C, Rattanapitoon SK.   +2 more
europepmc   +1 more source