Results 81 to 90 of about 297,227 (211)

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, EarlyView.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population: A Mendelian Randomization Study

Cancer Science, EarlyView.
Our Mendelian Randomization analysis provides evidence supporting a causal association between genetic predisposition to T2D, independent of BMI, and an increased risk of pancreatic cancer in the Japanese population, corroborating findings from observational studies.
Yingsong Lin, Haruki Sasado, Naoki Sasahira, Makoto Ueno, Hiroshi Ishii, Naoto Egawa, Yasushi Adachi, Masato Ozaka, Satoshi Kobayashi, Yuriko N. Koyanagi, Sayaka Yamamoto, Hidemi Ito, Akira Narita, Mika Sakurai‐Yageta, Takuji Okusaka, Aya Kuchiba, Teruhiko Yoshida, Fumihiko Matsuda, Yoichiro Kamatani, Shiori Nakano, Taiki Yamaji, Norie Sawada, Aya Kadota, Kiyonori Kuriki, Takeshi Watanabe, Nobuo Fuse, Kengo Kinoshita, Naoki Nakaya, Yoichi Sutoh, Yayoi Otsuka‐Yamasaki, Kozo Tanno, Ken Suzuki, Toshimasa Yamauchi, Takashi Kadowaki, BioBank Japan, Motoki Iwasaki, Sho Nakamura, Atsushi Hozawa, Atsushi Shimizu, Shogo Kikuchi, Masahiro Nakatochi, Keitaro Matsuo   +41 more
wiley   +1 more source

Dependence of Water-Permeable Chitosan Membranes on Chitosan Molecular Weight and Alkali Treatment

Membranes, 2020
Chitosan membranes were prepared by the casting method combined with alkali treatment. The molecular weight of chitosan and the alkali treatment influenced the water content and water permeability of the chitosan membranes. The water content increased as
Ryo-ichi Nakayama, Koki Katsumata, Yuta Niwa, Norikazu Namiki   +3 more
doaj   +1 more source

Role of freshwater availability and terrestrial land‐cover change in the distribution of a declining, terrestrial, insectivorous bird

Conservation Biology, EarlyView.
Abstract Insectivorous, Afro‐Palearctic migrant birds provide cross‐border ecosystem services, but many are declining rapidly. The complex life cycle of migrant birds makes their conservation difficult, but understanding where they spend time during the breeding season can help indicate where those actions will be most effective.
Catrin F. Eden, Simon Gillings, Richard K. Broughton, Bart Donato, Chris M. Hewson, Stuart P. Sharp   +5 more
wiley   +1 more source

Nakano's theorem revisited. [PDF]

Michigan Mathematical Journal, 1976
Aliprantis, C. D., Burkinshaw, O.
openaire   +2 more sources

Nakano-Nadel type, Bogomolov-Sommese type vanishing and singular dual Nakano semi-positivity

, 2022
In this article, we get properties for singular (dual) Nakano semi-positivity and obtain singular type vanishing theorem involving $L^2$-subsheaves on weakly pseudoconvex manifolds by $L^2$-estimates and $L^2$-type Dolbeault isomorphisms. As applications, Fujita's conjecture type theorem with singular Hermitian metrics is presented.
openaire   +2 more sources

Impact of Female Mating Status on Male Courtship Behaviour in a Sexually Cannibalistic New Zealand Fishing Spider

Ethology, EarlyView.
Scoring of male courtship behaviour in Dolomedes minor revealed no effect of female mating status on courtship duration or sequence structure, but males delayed the initiation of courtship when encountering previously mated females. ABSTRACT The evolution of male courtship rituals has traditionally been attributed to female mate selection, but may also
Bastien E. Clémot, Simon J. Connolly, Christina J. Painting   +2 more
wiley   +1 more source

Effects of Forage Rice Cultivation on Carbon and Greenhouse Gas Balances in a Rice Paddy Field

Atmosphere, 2018
The effects of conversion from staple rice to forage rice on carbon and greenhouse gas (GHG) balances in a paddy field were evaluated. A staple rice plot without the application of livestock manure compost (LMC, S − M plot) and forage rice plots ...
Fumiaki Takakai, Masahiro Kobayashi, Takashi Sato, Kentaro Yasuda, Yoshihiro Kaneta   +4 more
doaj   +1 more source

Clinical Outcomes of Reduced‐Dose Cabozantinib as Third‐ or Later‐Line Therapy After Immune Checkpoint Inhibitors in Advanced Hepatocellular Carcinoma: A Real‐World Study

Hepatology Research, EarlyView.
In this real‐world post‐ICI setting, cabozantinib demonstrated meaningful clinical activity even at reduced doses, with disease control achieved in nearly half of patients. Importantly, preserved liver function (Child–Pugh class A) was the only determinant of both disease control and overall survival.
Teiji Kuzuya, Hisanori Muto, Yoshihiko Tachi, Mizuki Ariga, Sayaka Morisaki, Gakushi Komura, Takuji Nakano, Hiroyuki Tanaka, Kazunori Nakaoka, Eizaburo Ohno, Kohei Funasaka, Mitsuo Nagasaka, Ryoji Miyahara, Yoshiki Hirooka   +13 more
wiley   +1 more source

Nakano teoremi

, 2020
In this thesis, it has been researched that in which circumstances it can be true which is known as Nakano Theorem, is generalized in . For this reason, the related parts of essay of W. A. J. Luxemburg and B. De Pagter, that is named by ?Maharam extensions of positive operators and f-modules?, has examined in a detailed way and it has tried research to
openaire   +1 more source