Results 251 to 260 of about 1,367 (297)

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

open access: yesAdvanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang   +10 more
wiley   +1 more source

Empowering Flexible Electronics with Piezoelectric Nanogenerators: Breakthroughs from Energy Harvesting to Intelligent Sensing

open access: yesAdvanced Science, EarlyView.
This review systematically summarizes recent advances in self‐powered flexible sensing and energy storage systems based on piezoelectric nanogenerators (PENGs). It highlights their fundamental mechanisms, structural designs, and applications in health monitoring, e‐skin, and tactile sensing. The integration of PENGs with supercapacitors or batteries is
Wu‐Lin Xin   +8 more
wiley   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

open access: yesAdvanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu   +7 more
wiley   +1 more source

High‐Security X‐Ray Imaging Encryption Based on Irreversible Acid‐Responsive Radioluminescence Memory Scintillator

open access: yesAdvanced Science, EarlyView.
An irreversible acid‐responsive radioluminescence memory scintillator, Zn1.3Ga1.4Ge0.3O4:Cr3+@Zn2GeO4:Eu3+ (ZGGO@ZGO), is developed in this work. The engineered dual‐layer security system composed of ZGGO@ZGO and ZGO achieves a combined effect of visual misdirection and sequential logic gates requiring acid treatment and CCD detection, significantly ...
Lin Liu   +7 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

open access: yesAdvanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li   +7 more
wiley   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

open access: yesAdvanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu   +12 more
wiley   +1 more source

Natural Acceptor of Coumarin-Isomerized Red-Emissive BioAIEgen for Monitoring Cu2+ Concentration in Live Cells via FLIM. [PDF]

open access: yesAdv Sci (Weinh)
Cai XM   +9 more
europepmc   +1 more source

Tailoring the Crystallization Behavior of Mixed Lead‐Tin Mixed‐Halide Perovskites for Optimal‐Bandgap Solar Cells

open access: yesAdvanced Science, EarlyView.
Carefully tuning the composition of mixed lead‐tin mixed iodide‐bromide perovskites results in an optimal‐bandgap semiconductor for solar energy conversion. Homogenous crystallization of this perovskite involves a short time delay between deposition of the precursor solution and applying an antisolvent. Using a bulk additive and top surface passivation
Lana M. Kessels   +6 more
wiley   +1 more source

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