Results 51 to 60 of about 1,367 (297)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Black holes surrounded by Einstein clusters as models of dark matter fluid
European Physical Journal C: Particles and Fields, 2023 We construct a novel class of spherically symmetric and asymptotically flat black holes and naked singularities surrounded by anisotropic dark matter fluid with the equation of state (EoS) of the form $$P_t=\omega \rho $$ P t = ω ρ .
Kimet Jusufi
doaj +1 more source
Gravitational lensing by rotating naked singularities [PDF]
Physical Review D, 2008 35 pages, 30 ...
Gyulchev, Galin N. +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Superentropic black hole shadows in arbitrary dimensions
European Physical Journal C: Particles and Fields, 2022 We investigate the shadow behaviors of the superentropic black holes in arbitrary dimensions. Using the Hamilton–Jacobi mechanism, we first obtain the associated null geodesic equations of motion. By help of a spheric stereographic projection, we discuss
A. Belhaj, M. Benali, Y. Hassouni
doaj +1 more source
Primordial naked singularities
Journal of Cosmology and Astroparticle PhysicsAbstract Primordial black hole formation has been discussed widely, when density perturbations in the early universe cause matter to collapse gravitationally, giving rise to these ultra-compact objects. We propose and point out that such a gravitational collapse would also give rise to primordial naked singularities, that would play an ...
Pankaj S. Joshi, Sudip Bhattacharyya
openaire +2 more sources
Naked singularities are not singular in distorted gravity
Nuclear Physics B, 2014 We compute the Zero Point Energy (ZPE) induced by a naked singularity with the help of a reformulation of the Wheeler-DeWitt equation. A variational approach is used for the calculation with Gaussian Trial Wave Functionals. The one loop contribution of the graviton to the ZPE is extracted keeping under control the UltraViolet divergences by means of a ...
GARATTINI, Remo, MAJUMDER, BARUN
openaire +3 more sources
Generic naked singularities in Vaidya spacetimes
Classical and Quantum Gravity, 2022 Abstract We investigate the occurrence of naked singularities, local and global, in the incoming Vaidya spacetimes with zero initial mass. While it is well-known that these spacetimes admit locally and globally naked singularities, we demonstrate that globally naked singularities are significantly more common than is stressed in the ...
openaire +2 more sources
Naked singularity explosion in higher dimensions [PDF]
Physical Review D, 2011 19 pages, 2 figures; v2: typos ...
Miyamoto, Umpei +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source