Results 71 to 80 of about 144,577 (185)

2011 assisted reproductive technology fertility clinic success rates report [PDF]

open access: yes
For many people who want to start a family, the dream of having a child is not easily realized; about 12% of women of childbearing age in the United States have used an infertility service.

core  

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

open access: yesMolecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke   +12 more
wiley   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

2012 Assisted reproductive technology fertility clinic success rates report [PDF]

open access: yes
For many people who want to start a family, the dream of having a child is not easily realized; about 12% of women of childbearing age in the United States have used an infertility service.

core  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

2016 Assisted reproductive technology fertility clinic success rates report [PDF]

open access: yes
For many people who want to start a family, the dream of having a child is not easily realized. Assisted reproductive technology (ART) has been used in the United States since 1981 to help patients become pregnant, most commonly through the transfer of ...

core  

Identification and characterisation of genetic variation in human health and disease

open access: yes
The emergence of population-level genomic databases and the adoption of cloud computing have led to the advent of population genomics, a field that aims to characterise genetic variation across tens of thousands of genomes.
Gudkov, Mikhail
core   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

2015 Assisted Reproductive Technology Fertility Clinic Success Rates Report [PDF]

open access: yes
The ART report provides an in-depth picture of the type, number, and outcome of ART cycles performed in U.S. fertility clinics. It includes individual clinic tables with ART success rates for 464 fertility clinics in operation in 2015 that provided and ...

core  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

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