Results 111 to 120 of about 2,836,177 (344)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Mining Brain Networks using Multiple Side Views for Neurological Disorder Identification

, 2015
Mining discriminative subgraph patterns from graph data has attracted great interest in recent years. It has a wide variety of applications in disease diagnosis, neuroimaging, etc.
Cao, Bokai, Kong, Xiangnan, Ragin, Ann B., Yu, Philip S., Zhang, Jingyuan   +4 more
core   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Weapon equipment question answering system based on BERT and knowledge graph [PDF]

Zhihui kongzhi yu fangzhen
Knowledge of weaponry and equipment is a crucial basis for formulating equipment utilization strategies and development pathways. To address issues such as data redundancy, high interaction difficulty, and low match accuracy of question answers, this ...
WANG Bo, JIANG Xuping, HUANG Qihong
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Research and Construction of Knowledge Map of Golden Pomfret Based on LA-CANER Model

Journal of Marine Science and Engineering
To address the issues of fragmented species information, low knowledge extraction efficiency, and insufficient utilization in the aquaculture domain, the main objective of this study is to construct the first knowledge graph for the Golden Pomfret ...
Xiaohong Peng, Hongbin Jiang, Jing Chen, Mingxin Liu, Xiao Chen   +4 more
doaj   +1 more source

Mercem: Method Name Recommendation Based on Call Graph Embedding [PDF]

2019 26th Asia-Pacific Software Engineering Conference (APSEC), 2019
Comprehensibility of source code is strongly affected by identifier names, therefore software developers need to give good (e.g. meaningful but short) names to identifiers. On the other hand, giving a good name is sometimes a difficult and time-consuming task even for experienced developers.
Hiroshi Yonai, Yasuhiro Hayase, Hiroyuki Kitagawa   +2 more
openaire   +3 more sources

The min-max edge q-coloring problem [PDF]

, 2013
In this paper we introduce and study a new problem named \emph{min-max edge $q$-coloring} which is motivated by applications in wireless mesh networks. The input of the problem consists of an undirected graph and an integer $q$.
Larjomaa, Tommi, Popa, Alexandru
core  

Where, how, and how much? A multicenter cohort study of the relationship between lupus decision aid modality, place of administration, interruption and viewing completeness and patient‐reported outcomes

Arthritis Care &Research, Accepted Article.
Objective We assessed whether shared decision‐making (SDM), and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE), differs by PtDA setting, modality, and the viewing experience.
Jasvinder A. Singh, Mark Beasley, Larry R. Hearld, for the Implementing DEcision‐Aid for Lupus in clinics (IDEAL) Consortium   +3 more
wiley   +1 more source

Eccentricity based topological indices of face centered cubic lattice FCC(n)

Main Group Metal Chemistry, 2021
Chemical graph theory has become a prime gadget for mathematical chemistry due to its wide range of graph theoretical applications for solving molecular problems.
Shaker Hani, Imran Muhammad, Sajjad Wasim   +2 more
doaj   +1 more source