Results 231 to 240 of about 86,271 (244)

DGCLCMI: a deep graph collaboration learning method to predict circRNA-miRNA interactions. [PDF]

BMC Biol
Cao C, Li M, Wang C, Xu L, Zou Q, Wang Y, Han W.   +6 more
europepmc   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

Advanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee, Loi Nguyen Dang, Jinsol Choi, Haesoo Kim, Lyndon Bastatas, Soyeun Park   +5 more
wiley   +1 more source

Chinese Clinical Named Entity Recognition With Segmentation Synonym Sentence Synthesis Mechanism: Algorithm Development and Validation.

JMIR Med Inform
Tang J, Huang Z, Xu H, Zhang H, Huang H, Tang M, Luo P, Qin D.   +7 more
europepmc   +1 more source

Efficient substructure feature encoding based on graph neural network blocks for drug-target interaction prediction. [PDF]

Front Pharmacol
Deng G, Shi C, Ge R, Hu R, Wang C, Qin F, Pan C, Mao H, Yang Q.   +8 more
europepmc   +1 more source

Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B

Advanced Science, EarlyView.
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang, Cong Sun, Chu Xie, Bing‐Zhen Cheng, Zheng‐Zhou Lu, Ge‐Xin Zhao, Sen‐Fang Sui, Mu‐Sheng Zeng, Zheng Liu   +8 more
wiley   +1 more source

Benchmarking molecular conformer augmentation with context-enriched training: graph-based transformer versus GNN models. [PDF]

J Cheminform
Valsecchi C, Arjona-Medina JA, Dyubankova N, Nugmanov R.   +3 more
europepmc   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

An Improved Knowledge Graph Representation for Ransomware Attacks Using LSTM-Based Named Entity Relation Technique and Twitter Data

Khalid Jameel Munshid
openalex   +2 more sources

From biomedical knowledge graph construction to semantic querying: a comprehensive approach. [PDF]

Sci Rep
Wang L, Hao H, Yan X, Zhou TH, Ryu KH.
europepmc   +1 more source

MAHE: a multiscale and hybrid expert-based model for image-text enhanced named entity recognition on social media. [PDF]

Sci Rep
Yang S, Mo B, Liu D, Zhu L.
europepmc   +1 more source