Results 251 to 260 of about 2,399,596 (329)

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

open access: yesAdvanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song   +24 more
wiley   +1 more source

Towards interpretable sleep stage classification with a multi-stream fusion network. [PDF]

open access: yesBMC Med Inform Decis Mak
Chen J   +6 more
europepmc   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

open access: yesAdvanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu   +10 more
wiley   +1 more source

From Code to Life: The AI‐Driven Revolution in Genome Editing

open access: yesAdvanced Science, EarlyView.
This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li   +10 more
wiley   +1 more source

A knowledge graph for crop diseases and pests in China. [PDF]

open access: yesSci Data
Yan R   +6 more
europepmc   +1 more source

Topology Augmented with Geometry in the Assembly of Structural Databases: Kagome Intermetallics

open access: yesAdvanced Science, EarlyView.
The combination of topological filtering with geometrical restraints reliably screens for kagome layers within intermetallic compounds. The resulting comprehensive list of kagome net‐containing intermetallics can be reviewed to identify examples of interest for particular investigations and also used to build ML models to guide the search for further ...
Nataliya L. Gulay   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy