Results 251 to 260 of about 554,031 (298)

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Construction of knowledge graph for gas polyethylene pipelines based on ALBERT-BiGRU-CRF. [PDF]

Sci Rep
Yu Z, Zhou J, Wang Q, Zhou H, Song Y, Zong C.   +5 more
europepmc   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Named Entity Recognition for Chinese Cancer Electronic Health Records-Development and Evaluation of a Domain-Specific BERT Model: Quantitative Study.

JMIR Med Inform
Chen J, Zhao B, Tian X, Zou Z, Wang R, Wu J, Du S, Guo F.   +7 more
europepmc   +1 more source

PathoGraph: A Graph-Based Method for Standardized Representation of Pathology Knowledge. [PDF]

Sci Data
Lou P, Dong Y, Ding C, Wang C, Guo R, Pang X, Wang C, Li C.   +7 more
europepmc   +1 more source

Global Evidence of the Unimodal Response of Ecosystem Respiration to Soil Moisture

Advanced Science, EarlyView.
Using global eddy covariance observations and a field experiment, this paper provides compelling evidence for the widespread unimodal relationship between soil moisture and ecosystem respiration and its water adaptation. Such knowledge facilitates understanding of soil moisture in affecting respiratory carbon emissions and has the potential to improve ...
Jinlong Peng, Shudi Xie, Jiwang Tang, Jiaqiang Liao, Chen Chen, Chuanlian Sun, Yiheng Wang, Qingping Zhou, Guirui Yu, Shuli Niu   +9 more
wiley   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

MFH-LPI: based on multi-view similarity networks fusion and hypergraph learning for long non-coding RNA-protein interactions prediction. [PDF]

BMC Genomics
Xing Z, Yu S, Liao S, Wang P, Liao B.
europepmc   +1 more source

Intrinsic MicroRNA‐10a Restricts Regulatory T Cell Suppressive Function and Intestinal Repair by Coordinating Transcriptional, Metabolic, and Epithelial Repair Pathways

Advanced Science, EarlyView.
This study identifies microRNA‐10a (miR‐10a) as a key brake on regulatory T cell (Treg) suppressive function and intestinal repair. By targeting Blimp‐1, Uqcrq, and amphiregulin, miR‐10a restrains transcriptional, metabolic, and epithelial programs essential for Treg activity.
Wenjing Yang, Tianming Yu, Hui Yang, Suxia Yao, Ruihua Ma, Elizabeth M Steinert, Karen M Ridge, Weiguo Cui, Navdeep S Chandel, Yingzi Cong   +9 more
wiley   +1 more source

Energy Landscape and Kinetic Analysis of Molecular Dynamics Simulations for Intrinsically Disordered Proteins. [PDF]

J Phys Chem B
Schäffler M, Wales DJ, Strodel B.
europepmc   +1 more source