Results 291 to 300 of about 2,399,596 (329)
Advanced Science, EarlyView.Can a generative model design molecules that truly understand their targets? BInD, a diffusion‐based framework, co‐generates 3D molecules and their interactions with proteins by learning target‐specific interacting patterns. With knowledge‐based guidance and NCI‐driven optimization, BInD balances affinity, geometry, and drug‐likeness – pushing the ...
Joongwon Lee +3 more
wiley +1 more source
MOLUNGN: a multi-omics graph neural network for biomarker discovery and accurate lung cancer classification. [PDF]
Front GenetZhang D, Bian G, Zhang Y, Xie J, Hu C.
europepmc +1 more source
Advanced Science, EarlyView.PRO‐LDM is a modular latent diffusion framework that learns hierarchical biological representations to enable efficient and high‐fidelity protein design. PRO‐LDM can design species that resemble natural sequences with enhanced diversity or optimize protein functions.
Sitao Zhang +15 more
wiley +1 more source
Research on a traditional Chinese medicine case-based question-answering system integrating large language models and knowledge graphs. [PDF]
Front Med (Lausanne)Duan Y +6 more
europepmc +1 more source
Advanced Science, EarlyView.This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai +6 more
wiley +1 more source
Enhancing biomedical named entity recognition with parallel boundary detection and category classification. [PDF]
BMC BioinformaticsWang Y, Tong H, Zhu Z, Hou F, Li Y.
europepmc +1 more source
Bio‐Inspired Strategy for Radiation‐Based Thermal Management and Utilization
Advanced Science, EarlyView.Biological organisms have evolved remarkable strategies to manage and exploit thermal radiation. This review explores bio‐inspired systems that mimic these adaptations—such as radiative cooling, thermal regulation, thermal insulation, water harvesting, infrared camouflage, and infrared detection—and highlights their application in thermal management ...
Hyung Rae Kim +5 more
wiley +1 more source
Computational modeling of infectious diseases: insights from network-based simulations on measles. [PDF]
BMC Med Inform Decis MakBranda F +5 more
europepmc +1 more source
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Advanced Science, EarlyView.Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska +18 more
wiley +1 more source