Results 201 to 210 of about 69,654 (255)

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

Nanotechnology in dermatologic therapy: clinical advances and emerging translational perspectives over the past decade. [PDF]

An Bras Dermatol
Cogo CPB, Ianhez M, Bertino R, Costa AA, Costa A, Miot HA.   +5 more
europepmc   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Translational advances in diabetic nephropathy management: integrating nanoformulation-based drug delivery systems. [PDF]

Front Med Technol
Ansari MD, Vishwakarma A, Quamuddin M, Aggarwal M, Khan H, Abd Jalil MF, Mahmood S, Wali AF, Talath S, El-Tanani M.   +9 more
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self‐Sorting of DNA Tiles With Precisely Controlled Hydrophobic Behavior

Angewandte Chemie, EarlyView.
DNA tile amphiphiles encode dual chemical information, directing nanostructure formation through base‐pairing and hydrophobic effects. Thermal annealing programs hierarchical assembly, with first‐formed interactions biasing the final morphology: short hydrophobic chain strands form DX‐tiles and then into stars, while long‐chain strands form SNAs and ...
Yihao Wu, Muhammad Ghufran Rafique, Christopher Saab, Hanadi Sleiman   +3 more
wiley   +2 more sources

From barrier to guide: Exploiting disease-specific hemodynamics for enhanced nanodrug targeting in cardiovascular diseases. [PDF]

Pharm Sci Adv
Wang Z, Chen X, Li Y, Zhai S, Guan Z, Zhang W.   +5 more
europepmc   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +2 more sources

Tumor microenvironment conversion through intelligent nanomedicine: a paradigm shift in overcoming chemoresistance. [PDF]

Front Oncol
Hasannia M, Abounoori M, Mahmoudian F, Shirzad M, Rahdar A, Duguna S, Pandey S.   +6 more
europepmc   +1 more source