Results 31 to 40 of about 102,003 (257)

Urea supplementation improves mRNA in vitro transcription by decreasing both shorter and longer RNA byproducts

RNA Biology
The current letter to the editor describes the presence of RNA byproducts in small-scale in vitro transcription (IVT) reactions as evaluated by capillary gel electrophoresis, asymmetric flow field flow fractionation, immunoblotting, cell-free translation
Combes Francis, Pettersson Frida J, Bui Thanh-Huong, Molska Alicja, Komissarov Artem, Parot Jérémie, Borgos Sven Even   +6 more
doaj   +1 more source

Editorial on Advanced Nanomedicine

, 2018
In advanced nanomedicine not only construction and repairing of human biological systems; but also monitoring and controlling can be implemented using nanostructures and nanobots at molecular level.
Mitra, Manu
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

A perspective on nanomedicine: focus on cardiovascular medicine

, 2019
Background: Nanomedicine refers to the application of nanotechnology to improve the diagnosis, monitoring and treatment of diseases. Although the primary application was originally in oncology, nanomedicine has witnessed substantial scientific interest ...
White, K., Shrestha, S., Tewfik, S., Minelli, C., Thapa, P., Tewfik, I.   +5 more
core   +3 more sources

Gb3/cd77 Is a Predictive Marker and Promising Therapeutic Target for Head and Neck Cancer

Biomedicines, 2022
Head and neck squamous cell carcinoma is the sixth leading cancer in the world. This cancer is difficult to treat and is characterized by recurrences that are often fatal.
Lorena García-Hevia, Débora Muñoz-Guerra, Íñigo Casafont, Carmelo Morales-Angulo, Victor J. Ovejero, David Lobo, Mónica L. Fanarraga   +6 more
doaj   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Supramolecular nanostructure mimics GDNF trophic effects in vitro on human dopaminergic neurons

npj Regenerative Medicine
Peptide-based supramolecular nanostructures offer a versatile platform with substantial promise for clinical translation in regenerative medicine.
Oscar A. Carballo-Molina, Alexandra N. Kolberg-Edelbrock, Matías Alvarez-Saavedra, Zaida Álvarez, Timmy Fyrner, Tamara Perez-Rosello, Zois Syrgiannis, Stacey M. Chin, Nozomu Takata, Madison Strong, Liam C. Palmer, D. James Surmeier, Samuel I. Stupp   +12 more
doaj   +1 more source

Discovery of MBL-AB01: a novel antibacterial xanthone antibiotic with high activity against methicillin-resistant Staphylococcus aureus

Applied and Environmental Microbiology
A novel compound denoted MBL-AB01 was isolated from a marine Actinoalloteichus, which belongs to a rare and underexplored class of Actinobacteria. This work demonstrates that the novel compound MBL-AB01 shows very high activity in vitro against six ...
Kristin Fløgstad Degnes, Anna Nordborg, Giang-Son Nguyen, Guro Kruge Nærdal, Tonje Marita Bjerkan Heggeset, Peter Molesworth, Sigrid Hakvåg, Randi Aune, Vu To Nakstad, Johan Evenäs, Klara Jonasson, Trond Erling Ellingsen, Alexander Wentzel, Geir Klinkenberg, Håvard Sletta   +14 more
doaj   +1 more source

Extracellular Vesicles as Drug Delivery Systems in Cancer

Pharmaceutics, 2020
Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against current treatments.
Laia Hernandez-Oller, Joaquin Seras-Franzoso, Fernanda Andrade, Diana Rafael, Ibane Abasolo, Petra Gener, Simo Schwartz Jr.   +6 more
doaj   +1 more source