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Cleaving DNA by nanozymes

Journal of Materials Chemistry B, 2020
Various nanomaterials can mimic the activities of nucleases for hydrolytic and oxidative DNA cleavage on different sites allowing interesting biomedical and bioanalytical applications.
Ruiqin Fang, Juewen Liu
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Hydrolytic Nanozymes

European Journal of Organic Chemistry, 2020
In 2004 we first reported catalytic nanoparticles, that are able to cleave phosphate diesters with very high efficiency (Angew. Chem. Int Ed, 2004, 43, 6165–6169) and dubbed them “nanozymes” for the similarity of their behavior with natural enzymes, both in terms of efficiency and mechanism of action.
Gabrielli L.   +4 more
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Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles

Science China Life Sciences, 2021
The iron oxide nanoparticles (IONPs) that combine the nanozyme activity and magnetothermal properties have attracted significant interest for various biomedical applications. However, the effect of magnetic stimulation in fine-tuning the nanozyme activities remains unclear.
Yuan, He   +7 more
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Amalgamation of DNAzymes and Nanozymes in a Coronazyme

Journal of the American Chemical Society, 2023
Artificial enzymes such as nanozymes and DNAzymes are economical and stable alternatives to natural enzymes. By coating Au nanoparticles (AuNPs) with a DNA corona (AuNP@DNA), we amalgamated nanozymes and DNAzymes into a new artificial enzyme with catalytic efficiency 5 times higher than AuNP nanozymes, 10 times higher than other nanozymes, and ...
Li Zuo   +8 more
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Nanozymes for Therapeutics

2020
Free radicals (ROS, NOS, etc.) play a vital role in the pathological process of many diseases from nerve and organ injury to cancer, tissue damage, and inflammatory disorders. Though moderate amount of free radicals helps maintain the normal body function and hamper the growth of bacteria, excessive amount of radicals will induce oxidative stress ...
Wen Cao   +3 more
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Cold‐Adapted Nanozymes

Advanced Healthcare Materials
AbstractCold‐adapted nanozymes represent a distinct class of nanomaterials that exhibit robust catalytic activity and stability under low‐temperature conditions (below 37 °C). By emulating the catalytic functions of natural enzymes, these nanozymes can overcome the inherent limitations of traditional enzymes, which typically suffer from the reduced ...
Tianye Zhang   +7 more
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Exploring the Specificity of Nanozymes

ACS Nano
Nanozymes, nanomaterials exhibiting enzyme-like activities, have emerged as a prominent interdisciplinary field over the past decade. To date, over 1200 different nanomaterials have been identified as nanozymes, covering four catalytic categories: oxidoreductases, hydrolases, isomerases, and lyases.
Huizhen Fan   +4 more
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Nanozyme‐based luminescence detection

Luminescence, 2020
AbstractNanozymes refer to nanomaterial‐based enzyme mimics. Most nanozyme assays use chromogenic molecules as substrates that can produce an absorbance change in the visible region upon reaction. For certain applications, such as imaging, fluorescence and luminescence signals are required.
Jinyi Zhang, Juewen Liu
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Recent Advances in Nanozyme Research

Advanced Materials, 2018
AbstractAs a new generation of artificial enzymes, nanozymes have the advantages of high catalytic activity, good stability, low cost, and other unique properties of nanomaterials. Due to their wide range of potential applications, they have become an emerging field bridging nanotechnology and biology, attracting researchers in various fields to design
Hui Wang, Kaiwei Wan, Xinghua Shi
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