Results 51 to 60 of about 114,045 (313)

Lost and found in translation: the value of the human imiquimod model

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs   +6 more
wiley   +1 more source

Teacher confidence and student engagement with mental health and wellbeing lessons: Learning from an iterative curriculum intervention in schools

open access: yesBritish Educational Research Journal, EarlyView.
Abstract The mental health and wellbeing of young people has received increasing attention in both research and the wider public discourse. There has been a marked rise in mental health conditions in young people, and the burden of care is increasingly transferred onto schools and teachers.
Thomas Godfrey‐Faussett   +6 more
wiley   +1 more source

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons

open access: yesStem Cell Reports, 2017
We recently developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof of principle, we examine the use of these cells in modeling of a monogenic form of severe obesity: PCSK1 deficiency.
Liheng Wang   +10 more
doaj   +1 more source

Extent, characteristics and policy applications of Key Biodiversity Areas

open access: yesBiological Reviews, EarlyView.
ABSTRACT A global standard for the identification of Key Biodiversity Areas (KBAs) was published 10 years ago to provide a unified set of criteria for identifying ‘sites of significance for the global persistence of biodiversity’. We review the initiative's origins, the KBA identification process, characteristics of the current network, threats, policy
Stuart H. M. Butchart   +57 more
wiley   +1 more source

Naomi Soldon: Labor Unions in Wisconsin

open access: yes, 2022
Labor unions have a long, proud history in the United States. Long before the term “union-buster” was even a glimmer in anyone’s eye, labor unions had started fighting for their rights and benefits.
Naomi Soldon
core   +1 more source

Beyond Profit: Do Mergers and Acquisitions and the Board of Directors Increase the Environmental, Social, and Governance?

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT This study examines the relationship between mergers and acquisitions (M&A), board characteristics, and ESG performance in BRICS companies, considering the moderating role of sectoral sensitivity. The study analyzes 11,402 observations from 2293 BRICS companies, employing Two‐Stage Least Squares (2SLS) to address endogeneity and logistic ...
Geovane Camilo dos Santos   +2 more
wiley   +1 more source

Food Contamination and Safety in Nigeria: A Systematic Synthesis of Heavy Metals, Microbial Pathogens, and Health Risk Metrics

open access: yesFood Safety and Health, EarlyView.
This is an infographic driver of food contaminants and health effects. ABSTRACT Food safety remains a critical challenge in Nigeria due to rapid urbanization and weak regulatory enforcement. This systematic review synthesizes empirical evidence from 2015 to 2025 to characterize food contaminant profiles and associated human health risks in Nigeria ...
Cecilia Nwadiuto Obasi   +6 more
wiley   +1 more source

Timing of conception after methotrexate and subsequent pregnancy outcomes: A retrospective cohort study

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Methotrexate is widely used to treat ectopic pregnancy (EP). Concerns about its teratogenicity have led to uncertainty regarding the optimal interval before attempting conception. Guidelines recommend a 3‐month washout period, while the manufacturer advises 6 months. Evidence on the safety of early conception is limited.
Bar Rosh, Joul Hadad, Naomi Gronich
wiley   +1 more source

Emerging Scholar Profile- Dr. Naomi F. Dale

open access: yes, 2019
Dr Naomi Dale is an Assistant Professor of Management and Program Director of the Bachelor of Event and Tourism Management for the Faculty of Business, Government and Law at the University of Canberra.
Dale, Naomi F
core   +1 more source

Patient and public involvement in randomized trials of lifestyle intervention among pregnant women with obesity: An umbrella review

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Obesity increases the risk of obstetric and neonatal complications, and adherence to lifestyle interventions during pregnancy presents a challenge. Patient and public involvement (PPI) in trials may foster a more patient‐centered approach, potentially improving compliance with intervention and follow up.
Elisabeth Garcia Vilaplana   +6 more
wiley   +1 more source

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