Results 121 to 130 of about 176,510 (384)

RNF168 dephosphorylation ameliorates cognitive decline in Aβ-based mouse models of Alzheimer’s disease

Acta Neuropathologica Communications
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder among the elderly, with limited effective treatments available in clinical practice.
Miao-Jin Ji, Yun Li, Jiao Yang, Kangjunjie Wang, Shuning Sang, Hong Yang, Chenhao Tian, Xin Tang, Ji-Heng Cai, Tianhan He, Cheng Zhang, Huanyao Tang, Tiantao Cui, Xinran Meng, Xiang Cao, Jiaqi Zhu, Jie Wang, Jun-Li Cao, Daming Gao, Chao Liu   +19 more
doaj   +1 more source

Cannabis shenanigans: advocating for the restoration of an effective treatment of pain following spinal cord injury. [PDF]

, 2018
Cannabis is an effective treatment for pain following spinal cord injury that should be available to patients and researchers. The major argument against the rescheduling of cannabis is that the published research is not convincing.
Graves, PhD, Daniel E.
core   +1 more source

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

On Assessment of the Supreme Court Decisions in Tackling Substance Misuse in Indonesia [PDF]

This study aims to analyse the Indonesian Supreme Court (Mahkamah Agung) decisions to the defendants of substance misuse. The data were based on the Supreme Court decisions for substance misuse cases from 2001-2009, uploaded in putusan.mahkamahagung.or ...
Pradiptyo, Rimawan, Saputra, Sony
core   +1 more source

Safe Mobility in Hospitalised Older Adults: A Concept Analysis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To conduct a concept analysis of ‘safe mobility’, with specific application in hospitalised older adults, identifying its defining attributes, antecedents and consequences. Background The promotion of safe mobility is essential for maintaining the functionality of hospitalised older adults.
Esther Mourão Nicoli, Frances Valéria Costa e Silva, Rosane Barreto Cardoso, Tallita Mello Delphino, Luciana Guimarães Assad, Samara Gonçalves de Oliveira   +5 more
wiley   +1 more source

Confronting the opioid crisis: Practical pain management and strategies: AOA 2018 critical issues symposium [PDF]

, 2019
The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management.
Hsu, Joseph R, Jahangir, A Alex, Miller, Anna N, Mir, Hassan R, Obremskey, William T   +4 more
core   +1 more source

Challenges of Parents While Providing Complex Medical Care at Home to Children With Cancer: A Cross‐Sectional Convergent Mixed Methods Study

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To explore challenges parents of children with cancer encounter while providing complex medical care at home. Methods Design: Cross‐sectional convergent mixed‐methods study. Instruments: Questionnaire and open interviews that mirrored and complemented each other.
Rachel Klausner Shyman, Sveta Roberman, Gal Goldstein, Sabaa Masarwe, Amy Solnica, Rachel Yaffa Zisk‐Rony   +5 more
wiley   +1 more source

Efektifitas Penerapan Pidana Kurungan Bagi Pelaku Penyalahgunaan Narkotika [PDF]

, 2015
Act number 35 in 2009 provides severe criminal sanction for narcotic abuser in forms of imprisonment and fine sanctions. However, the narcotic abusers are in fact increasing.
Jainah, Z. O. (Zainab)
core  

Artificial Intelligence Technologies Supporting Nurses' Clinical Decision‐Making: A Systematic Review

Journal of Clinical Nursing, EarlyView.
ABSTRACT Background The use of technology to support nurses' decision‐making is increasing in response to growing healthcare demands. AI, a global trend, holds great potential to enhance nurses' daily work if implemented systematically, paving the way for a promising future in healthcare.
Kristina Mikkonen, Saara Tuunainen, Anne Oikarinen, Miia Jansson, Brigitte Woo, Wentao Zhou, Wilson Tam, Anna‐Maria Tuomikoski, Pirjo Kaakinen, Jonna Juntunen, Erika Jarva   +10 more
wiley   +1 more source

Local News Deserts and Community Social Capital Erosion

Journal of Regional Science, EarlyView.
ABSTRACT The disappearance of local newspapers across the United States has sparked growing concern about its implications for community life in rural America. This study examines the societal consequences of local news deserts, focusing on three critical dimensions of community social capital: crime, civic engagement, and political polarization. Using
Tess Haddock, K. Aleks Schaefer, Brian E. Whitacre, Trey Malone   +3 more
wiley   +1 more source