Results 181 to 190 of about 133,497 (331)

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1889-1899, December 2025.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima   +5 more
wiley   +1 more source

Preoperative knee joint hypothermia reduces inflammation and recovery time and increases range of motion after total knee arthroplasty: A randomized controlled trial

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 12, Page 4312-4323, December 2025.
Abstract Purpose Cryotherapy modulates synovial fluid composition by reducing inflammatory mediators and altering metabolite concentrations, resulting in both anti‐inflammatory and anti‐oxidative effects. The aim was to investigate whether preoperative cryocompression would (1) maintain deep tissue hypothermia during the surgical procedure, (2 ...
Leonardo Pieri   +5 more
wiley   +1 more source

Narcotics Do Not Alter the Heat Response of Unmyelinated Primary Afferents in Monkeys [PDF]

open access: bronze, 1986
Srinivasa N. Raja   +3 more
openalex   +1 more source

Reviewing the Potential for Behavioral Guidance to Improve Downstream Passage of Out‐Migrating Anguillid Eels

open access: yesRiver Research and Applications, Volume 41, Issue 10, Page 2287-2296, December 2025.
ABSTRACT Hydroelectric dams and their turbine infrastructure threaten out‐migrating anguillid eels en route to marine spawning grounds. For decades, invested parties have attempted to guide eels away from turbines and toward safe passage routes. A subset of this work (hereafter behavioral guidance) has involved exploiting sensory biology (e.g., sight ...
M. E. Cole MacLeod   +4 more
wiley   +1 more source

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