Results 51 to 60 of about 132,409 (312)

Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction

Cellular & Molecular Biology Letters
Background Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses a significant threat to their postoperative quality of life and overall well-being.
Wei-Feng Wu, Chen Chen, Jia-Tao Lin, Xin-Hao Jiao, Wei Dong, Jie Wan, Qiang Liu, Yong-Kang Qiu, Ao Sun, Yi-Qi Liu, Chun-Hui Jin, He Huang, Hui Zheng, Cheng-Hua Zhou, Yu-Qing Wu   +14 more
doaj   +1 more source

Treatment of Solitary Painful Osseous Metastases with Radiotherapy, Cryoablation or Combined Therapy: Propensity Matching Analysis in 175 Patients [PDF]

, 2015
aim of this study was to identify outcomes in pain relief and quality of life in patients with a solitary painful osseous metastasis treated by radiotherapy, cryoablation or the combination using a propensity score matching study ...
Bonfili, Pierluigi, Di Cesare, Ernesto, Di Staso, Mario, Franzese, Pietro, Gravina, GIOVANNI LUCA, Gregori, Lorenzo, Marampon, Francesco, Masciocchi, Carlo, Moro, Roberto, Tombolini, Vincenzo, Vittorini, Francesca, Zugaro, Luigi   +11 more
core   +3 more sources

Effects of integrated programs for substance‐involved mothers on infant and child development outcomes: A systematic review and meta‐analysis

Infant Mental Health Journal: Infancy and Early Childhood, EarlyView.
Abstract Maternal substance use is a pressing public health issue that confers risk for maternal health, the parent‐infant relationship, and child development. Integrated interventions that jointly address maternal substance use and child development have shown promise for enhancing child outcomes.
Sophie Barriault, Mary Motz, Lamia Firasta, Hannah McDowell, Patrick R. Labelle, Nancy Poole, Nicole Racine   +6 more
wiley   +1 more source

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

Comparison of Clinical Personality Patterns and Severe Personality Pathologies in Narcotic Substance Abusers with and Without Non-suicidal Self-Injury [PDF]

روانشناسی بالینی و شخصیت
Introduction: Due to personality issues, individuals who abuse narcotic substances are more prone to self-harm than the general population. The aim of this study is to compare clinical personality patterns and severe personality pathologies in narcotic ...
Azar Kiamarsi
doaj   +1 more source

Analyzing the Open/Deep Web to Better Understand the New/Novel Psychoactive Substances (NPS) Scenarios: Suggestions from CASSANDRA and NPS.Finder Research Projects

Brain Sciences, 2020
New/novel psychoactive substances (NPS) are defined as new narcotic/psychotropic drugs which are not controlled by the United Nations’ 1961 Narcotic Drugs/1971 Psychotropic Substances conventions, but which may pose a public health threat [...]
Fabrizio Schifano
doaj   +1 more source

Immediate postoperative anesthesia with either lidocaine or bupivacaine: A short‐term clinical response

Journal of Periodontology, EarlyView.
Abstract Background The purpose of this randomized, three‐armed clinical trial is to determine if a postoperative injection of 0.5% bupivacaine is more effective than 2% lidocaine in controlling pain after periodontal flap surgery. Methods Seventy‐six patients planned for similar periodontal surgeries were included.
Jessica D. Koster, David E. Deas, Archontia Palaiologou, David J. Lasho, Anibal Diogenes   +4 more
wiley   +1 more source

Toxic megacolon: A rare presentation and novel treatment

JPGN Reports, EarlyView.
Abstract A 14‐year‐old male presented with toxic megacolon (TM). Stool culture and rectal biopsies ruled out Clostridium difficile infection and Hirschsprung disease, respectively. Anorectal manometry ruled out anal achalasia as rectoanal inhibitory reflex elicited a normal resting pressure.
Adrienne P. Davis, Jennifer M. Schuh, Janice Bitong, Amy J. Wagner   +3 more
wiley   +1 more source

ACUTE NARCOTIC DRUG INTOXICATIONS: ETIOLOGY, SEX/AGE DISTRIBUTION AND CLINICAL OUTCOME [PDF]

Journal of IMAB, 2017
Purpose: Poisoning with drugs is a serious medical and social problem worldwide. Retrospective analysis of acute poisoning with narcotic drugs had been performed in Varna region for 25 years (1991-2015).
Petko Marinov, Snezha Zlateva, Georgi Bonchev, Dobri Ivanov, Kaloyan Georgiev, Yulichka Sabeva, Marieta Yovcheva   +6 more
doaj   +1 more source

Treatment of large chondral lesions with an autologous minced cartilage technique and synovial flap leads to superior results compared to matrix associated autologous chondrocyte transplantation technique after 24 months: A controlled clinical trial

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Treating large cartilage lesions in the knee remains a challenge. While matrix‐associated autologous chondrocyte implantation (MACI) is the gold standard for medium to large lesions, the minced cartilage technique has shown promise in smaller defects. Enhancing this technique with biomaterials has been suggested for larger lesions, but
Johanna Mayr, Franziska Warth, Nicola Oehler, Martin Majewski, Christoph Lutter, Fabian Blanke   +5 more
wiley   +1 more source