Results 61 to 70 of about 129,991 (344)

Identification of Tetrahydrocannabidiol Metabolites in Human Urine

open access: yesDrug Testing and Analysis, EarlyView.
The detection of Phase I and II metabolites of tetrahydrocannabidiol (H4CBD) in urine after oral ingestion of 25‐mg H4CBD by a volunteer is described. The proposed metabolite structures are based on ESI+ spectra recorded by HPLC‐HRMS and EI spectra after trimethylsilylation recorded by GC–MS.
Willi Schirmer   +3 more
wiley   +1 more source

Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction

open access: yesCellular & Molecular Biology Letters
Background Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses a significant threat to their postoperative quality of life and overall well-being.
Wei-Feng Wu   +14 more
doaj   +1 more source

Hidden Costs of Ban the Box Laws: Unraveling the Effects on Drug‐Related Deaths

open access: yesHealth Economics, EarlyView.
ABSTRACT Ban the Box (BTB) laws delay criminal background checks until the later stages of the hiring process. This study provides new evidence that BTB laws that apply to both private and public employers have negative spillover effects beyond labor market outcomes.
Oleksandra Cheipesh
wiley   +1 more source

Potentiometric Signal Transduction for Selective Determination of 1-(3-Chlorophenyl)piperazine “Legal Ecstasy” Through Biomimetic Interaction Mechanism

open access: yesChemosensors, 2019
1-(3-chlorophenyl)piperazine (mCPP) is a wide spread new psychoactive substance produces stimulant and hallucinogenic effects similar to those sought from ecstasy.
Eman H. El-Naby
doaj   +1 more source

Post‐Thyroidectomy Opioid Prescription and Risk of Persistent Opioid Use: A Propensity Matched Cohort Study

open access: yesHead &Neck, EarlyView.
ABSTRACT Background This study evaluates the risk of persistent opioid use (POU) among thyroidectomy patients given postoperative opioids. Methods Patients undergoing thyroidectomy were identified using the TriNetX Research Platform (2010–2024). Cohorts were divided based on opioid prescriptions on the day of surgery.
Oluwatobiloba Ayo‐Ajibola   +4 more
wiley   +1 more source

Identifying the main factors affecting the distribution of narcotic drugs with a qualitative approach

open access: yesJournal of Pharmacoeconomics and Pharmaceutical Management, 2023
Background: Narcotic drugs are used as an effective analgesic in diseases such as cancers and malignancies after surgery and addiction treatment. The available data show that the burden of addiction in Iranian society is not decreasing despite several ...
Hossein Rastegar   +2 more
doaj  

Effects of integrated programs for substance‐involved mothers on infant and child development outcomes: A systematic review and meta‐analysis

open access: yesInfant Mental Health Journal: Infancy and Early Childhood, EarlyView.
Abstract Maternal substance use is a pressing public health issue that confers risk for maternal health, the parent‐infant relationship, and child development. Integrated interventions that jointly address maternal substance use and child development have shown promise for enhancing child outcomes.
Sophie Barriault   +6 more
wiley   +1 more source

Systematic Literature Review of Spinal Cord Stimulation in Patients With Chronic Back Pain Without Prior Spine Surgery

open access: yesNeuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Low back pain is the leading cause of disability worldwide and one of the most common reasons for seeking healthcare. Despite numerous care strategies, patients with low back pain continue to exhibit poor outcomes. Spinal cord stimulation (SCS) is an evidence‐based therapeutic modality for patients with failed back surgery syndrome ...
Jan M. Eckermann   +5 more
wiley   +1 more source

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima   +5 more
wiley   +1 more source

The Influence of Gene Polymorphism OPRM1 118A/G on the Perception of Pain and Pharmacodynamics of Narcotic Analgesics

open access: yesОбщая реаниматология, 2014
The polymorphism of μ-opioid receptor is one of the most studied polymorphisms that affect the activity of narcotic analgesics. Despite that there are a large number of publications dealing with the problem, the obtained results are not being currently ...
V. M. Zhenilo, O. A. Makharin
doaj   +1 more source

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