Results 61 to 70 of about 166,224 (384)

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

open access: yesCell Death and Disease
Neuroinflammation is a key factor in the pathogenesis of Parkinson’s disease (PD). Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. However, the role of peripheral
Wei Song   +7 more
doaj   +1 more source

Optimizing Pain Control in a Patient with Lumbar Spinal Stenosis: A Report of Clinical Management

open access: yesClinical Management Issues, 2018
Lumbar spinal stenosis is a leading cause of low back pain and one of the most common causes of work absences. Treatment is initialized with narcotic and non-narcotic medications, which have been shown to work in the majority of patients.
Raymond E. Kennedy   +1 more
doaj   +1 more source

Development and Initial Use of a New Inflammatory Bowel Disease Clinical Database Integrating Both Eastern and Western Clinical Characteristics

open access: yesChronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background The increasing incidence of inflammatory bowel disease (IBD) presents significant medical and societal challenges. A well‐designed IBD database is crucial for both epidemiological studies and clinical management. However, inconsistencies between regional databases hinder cross‐institutional and international research, especially ...
Jingshuang Yan   +12 more
wiley   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

open access: yesDrug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis   +2 more
wiley   +1 more source

Modeling Policy and Agricultural Decisions in Afghanistan [PDF]

open access: yes, 2011
Afghanistan is responsible for the majority of the world's supply of poppy crops, which are often used to produce illegal narcotics like heroin. This paper presents an agent-based model that simulates policy scenarios to characterize how the production of poppy can be dampened and replaced with licit crops over time.
arxiv   +1 more source

Review of Peer-to-Peer Botnets and Detection Mechanisms [PDF]

open access: yesarXiv, 2022
Cybercrimes are becoming a bigger menace to both people and corporations. It poses a serious challenge to the modern digital world. According to a press release from 2019 Cisco and Cybersecurity Ventures, Cisco stopped seven trillion threats in 2018, or 20 billion threats every day, on behalf of its clients.
arxiv  

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

open access: yesDrug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer   +13 more
wiley   +1 more source

Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction

open access: yesCellular & Molecular Biology Letters
Background Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses a significant threat to their postoperative quality of life and overall well-being.
Wei-Feng Wu   +14 more
doaj   +1 more source

FEATURES OF STORAGE AND TRANSPORTATION OF NARCOTIC ANALGESICS IN CONDITIONS OF EMERGENCY SITUATIONS

open access: yesФармация и фармакология (Пятигорск), 2015
The article performs the analysis of the current state regulatory-legal framework relating to the use of narcotic analgesics in health care institutions in emergencies peace and wartime.There are developed recommendations for adapting the requirements ...
P. V. Oliynyk, B. P. Hromovyk
doaj   +1 more source

Sports Supplement Analysis Survey for the Prevalence of WADA Prohibited Substances in the Australian Online Marketplace

open access: yesDrug Testing and Analysis, EarlyView.
A survey of 200 sports supplements purchased online in Australia and analysed for WADA Prohibited Substances. Athlete education regarding the use of sports supplements remains a high priority as 35% of the products contained WADA Prohibited Substances. ABSTRACT Sports supplements are used extensively by people involved in competitive sports. However, a
Louise Barker   +4 more
wiley   +1 more source

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