Results 11 to 20 of about 6,465 (87)

Antipruritic Effect of Nalbuphine, a Kappa Opioid Receptor Agonist, in Mice: A Pan Antipruritic

Molecules, 2021
Antipruritic effects of kappa opioid receptor (KOR) agonists have been shown in rodent models of acute and chronic scratching (itchlike behavior). Three KOR agonists, nalfurafine, difelikefalin, and nalbuphine, are in clinical studies for antipruritic ...
Saadet Inan, Nae J. Dun, Alan Cowan
doaj   +1 more source

Physicochemical Characterizations and Pharmacokinetic Evaluation of Pentazocine Solid Lipid Nanoparticles against Inflammatory Pain Model

Pharmaceutics, 2022
Pentazocine (PTZ), a narcotic-antagonist analgesic, has been extensively used in the treatment of initial carcinogenic or postoperative pain. Hepatic first-pass metabolism results in low oral bioavailability and high dose wastage.
Zaheer Ullah Khan, Anam Razzaq, Ahsan Khan, Naeem Ur Rehman, Hira Khan, Taous Khan, Ashraf Ullah Khan, Norah A. Althobaiti, Farid Menaa, Haroon Iqbal, Naveed Ullah Khan   +10 more
doaj   +1 more source

Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. [PDF]

PLoS ONE, 2013
Novel classes of pain-relieving molecules are needed to fill the void between non-steroidal anti-inflammatory agents and narcotics. We have recently shown that intraplantar administration of sphingosine 1-phosphate (S1P) in rats causes peripheral ...
Amanda Finley, Zhoumou Chen, Emanuela Esposito, Salvatore Cuzzocrea, Roger Sabbadini, Daniela Salvemini   +5 more
doaj   +1 more source

Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice

Journal of Pharmacological Sciences, 2007
In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain.
Atsushi Sasaki, Yasutaka Nakashima, Ichiro Takasaki, Tsugunobu Andoh, Kimiyasu Shiraki, Yasushi Kuraishi   +5 more
doaj   +1 more source

Medical expulsive therapy

Indian Journal of Urology, 2014
The objective of this review article is to present the current literature on medical expulsive therapy (MET) and help guide practitioners in the appropriate use of MET for treatment of stone disease.
Kyle D Wood, Ilya Gorbachinsky, Jorge Gutierrez   +2 more
doaj   +1 more source

Comparative study of intrathecal dexmedetomidine, fentanyl, and magnesium sulfate as adjuvants to 0.5% hyperbaric bupivacaine for knee arthroscopic surgeries

Al-Azhar Assiut Medical Journal
Background and aim Fentanyl is one of the short-acting narcotic analgesics with potent morphine-like action. Dexmedetomidine is a highly selective α2 adrenergic agonist which has been used for premedication and as an adjunct to general anesthesia.
Osama H. Ahmed, Mahmoud A. Abdelsalam, Mohamed A. Makhlouf   +2 more
doaj   +1 more source

Synergistic Photo‐Electro‐Fenton Oxidation of Antibiotics Using a Ferrocene‐Functionalized MXene (Ti3C2Tx) Electrode

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
2D MXene (Ti3C2Tx)‐based electrode setup for hybrid photo‐electro‐Fenton degradation of antibiotic (tetracycline). The persistence of antibiotics such as tetracycline in aquatic systems poses severe environmental and health risks by potential antimicrobial resistance.
Durga Sankar Vavilapalli, Gordian Sandberg, Leiqiang Qin, Joseph Halim, Andrejs Petruhins, Daniel Dahlberg, Markus Axelsson, Anneli Kruve, Johanna Rosen   +8 more
wiley   +1 more source

Updated ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease 2025

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To revise the 2018 European Reference Network for rare Inherited and Congenital Digestive and Gastrointestinal Anomalies (ERNICA) clinical guideline for the management of rectosigmoid Hirschsprung's disease (HSCR) based on new evidence and evolving clinical priorities, ensuring continued relevance, trustworthiness, and consistency ...
Daniel Rossi, Willemijn Irvine, Anna Löf Granström, Annika Mutanen, Roel Bakx, Kristin Bjørnland, Duccio Cavalieri, Piotr Czauderna, Anne Dariel, Mark Ellebæk, Francesco Fascetti Leon, Fabio Fusaro, Dirk‐Jan Gloudemans, Marietta Jank, Peter Kolja Kvist, Martin Lacher, Annette Lemli, Lucas Matthyssens, Louise Montalva, Pedro Palazon, Alessio Pini Prato, Lucie Pos, Roxana Rassouli‐Kirchmeier, Konrad Reinshagen, Nagoud Schukfeh, Rony Sfeir, Olivia Spivack, Pernilla Stenström, Lovisa Telborn, Eelke Toxopeus, Alejandra Vilanova, Miriam Wilms, Rene Wijnen, Cornelius E. J. Sloots, Mikko Pakarinen, Tomas Wester   +35 more
wiley   +1 more source

Science as an Antagonist in Dannie Abse's poetry

Social Sciences and Humanities Open
This article examines Dannie Abse’s attitude toward science through a close reading and analysis of some of his selected poems. He is a physician who uses poetry as a means for critique, of science in general and medicine in particular, for he believes ...
Zaynab Layth Abdul Jabbar, Wafaa Abdullatif Abdulaali   +1 more
doaj   +1 more source

Epidemiological Signals, Knowledge Gaps, and Practice Considerations From the 2024 Functional Neurological Disorder Society International Meeting: A Conference Report With Narrative Synthesis

Medicine Bulletin, EarlyView.
ABSTRACT The 2024 International Conference on Functional Neurological Disorders brought together clinicians, researchers, advocates, and service‐user representatives to discuss recent developments in functional neurological disorder and related functional disorders.
Yadira Velazquez‐Rodriquez, Jennifer Brown, Katherine Gill   +2 more
wiley   +1 more source