Results 201 to 210 of about 54,328 (276)

Sulfonamide‐Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study

open access: yesPharmacology Research &Perspectives, Volume 13, Issue 2, April 2025.
ABSTRACT The research and design of new inhibitors for the treatment of diseases such as Alzheimer's disease and glaucoma through inhibition of cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and carbonic anhydrase enzymes are among the important targets.
Nebih Lolak   +8 more
wiley   +1 more source

Transcutaneous Auricular Vagus Nerve Stimulation Restores Cognitive Impairment in Morphine‐Withdrawn Rats: Role of BDNF and Glial Cells in the Hippocampus

open access: yesAddiction Biology, Volume 30, Issue 4, April 2025.
Transcutaneous auricular vagus nerve stimulation (taVNS) for 2 weeks at three different frequencies ameliorated the impairment of working and recognition memory induced by morphine. Additionally, it exerts an anxiolytic effect. Moreover, taVNS counteracted the decreased concentration of BDNF and elevated levels of GFAP caused by morphine.
Somayeh Nazari   +6 more
wiley   +1 more source

Trajectories of NEET in individuals formerly placed in out‐of‐home care: A Swedish national cohort study

open access: yesInternational Journal of Social Welfare, Volume 34, Issue 2, April 2025.
Abstract It is widely acknowledged that individuals with out‐of‐home care (OHC) experiences, including foster‐family care and residential care, face an increased risk of poor labour market attachment during emerging adulthood. However, limited understanding exists regarding how this attachment, conceptualized here as ‘not in employment, education, or ...
Lars Brännström   +3 more
wiley   +1 more source

Are “Alternative to Discipline” Programs for Nurses With Alcohol and Other Drug Challenges Relevant to Global Contexts? A Scoping Review

open access: yesInternational Journal of Mental Health Nursing, Volume 34, Issue 2, April 2025.
ABSTRACT Alternative to discipline programs, defined as programs for nurses ‘impaired’ by issues such as alcohol and/or drug use, provide treatment and support to return to the profession. This paper aims to explore alternative to discipline programs for nurses to determine whether these programs are relevant to other geographical contexts.
Adam Searby   +3 more
wiley   +1 more source

Analysis and study of the mechanism of narcotic addiction and withdrawal

open access: yesHeliyon
Narcotic drugs refer to drugs that have anesthetic effects on the central nervous system, and they easily produce physical dependence and mental dependence and can be addictive due to continuous use, abuse or unreasonable use.
Yan Wang   +7 more
doaj  

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