Results 191 to 200 of about 175,013 (307)

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

open access: yesThe Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1889-1899, December 2025.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima   +5 more
wiley   +1 more source

Narcotics Do Not Alter the Heat Response of Unmyelinated Primary Afferents in Monkeys [PDF]

open access: bronze, 1986
Srinivasa N. Raja   +3 more
openalex   +1 more source

Preoperative knee joint hypothermia reduces inflammation and recovery time and increases range of motion after total knee arthroplasty: A randomized controlled trial

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 12, Page 4312-4323, December 2025.
Abstract Purpose Cryotherapy modulates synovial fluid composition by reducing inflammatory mediators and altering metabolite concentrations, resulting in both anti‐inflammatory and anti‐oxidative effects. The aim was to investigate whether preoperative cryocompression would (1) maintain deep tissue hypothermia during the surgical procedure, (2 ...
Leonardo Pieri   +5 more
wiley   +1 more source

Role of Pain in Adults Undergoing Soft Tissue and Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea

open access: yesLaryngoscope Investigative Otolaryngology, Volume 10, Issue 6, December 2025.
ABSTRACT Objective In adult patients who undergo soft tissue and maxillomandibular advancement (MMA) sleep surgery for obstructive sleep apnea (OSA), we identify preoperative pain diagnoses and postoperative pain medication dispensing patterns by surgery type.
Ghedak Ansari   +4 more
wiley   +1 more source

Deliberate self‐harm in adolescents with OTC‐related psychiatric disorders: A study of prevalence and associated factors

open access: yesPsychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Aim This study examines the issues of over‐the‐counter (OTC) drug abuse among adolescents from the perspective of deliberate self‐harm and suicide. It aims to elucidate the clinical characteristics of psychiatric disorders related to OTC drug use and explore treatment approaches in the context of self‐harm and suicide prevention.
Toshihiko Matsumoto   +5 more
wiley   +1 more source

Reviewing the Potential for Behavioral Guidance to Improve Downstream Passage of Out‐Migrating Anguillid Eels

open access: yesRiver Research and Applications, Volume 41, Issue 10, Page 2287-2296, December 2025.
ABSTRACT Hydroelectric dams and their turbine infrastructure threaten out‐migrating anguillid eels en route to marine spawning grounds. For decades, invested parties have attempted to guide eels away from turbines and toward safe passage routes. A subset of this work (hereafter behavioral guidance) has involved exploiting sensory biology (e.g., sight ...
M. E. Cole MacLeod   +4 more
wiley   +1 more source

Ghosting at the border: the racialization of extraterritoriality at the US Supreme Court Les limbes de la frontière : racialisation de l'extraterritorialité par la Cour suprême des États‐Unis

open access: yesJournal of the Royal Anthropological Institute, Volume 31, Issue 4, Page 1116-1135, December 2025.
The theoretical association of an inclusive public sphere with liberal democratic governing begs a closer examination. This article pursues forms of disqualification implicit in the idea of political community as a national project, ultimately finding that the exclusion of foreigners does not begin on the far side of the US border, but well within it ...
Carol J. Greenhouse
wiley   +1 more source

A Review of Exercise Interventions for Rehabilitation in Drug‐Dependent Individuals

open access: yesAddiction Biology, Volume 30, Issue 12, December 2025.
The analysis of 39 core studies indicates that diverse exercise interventions have varying positive effects across different dimensions for various addiction populations. Exercise can exert beneficial impacts on the neurobiological mechanisms, as well as physiological and psychological aspects, of individuals with drug addiction.
Qinghua He   +8 more
wiley   +1 more source

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