Results 241 to 250 of about 48,291 (295)

The neuroprotective mechanisms of naringenin: Inhibition of apoptosis through the PI3K/AKT pathway after hypoxic-ischemic brain damage.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Naringenin (NGN) is a widely distributed flavonoid with potent antioxidant and neuroprotective properties. Neuroprotective agents play a crucial role in the treatment of hypoxic-ischemic encephalopathy (HIE).
Luyao Li, Zhenlang Lin, Junhui Yuan, Ping-Yang Li, Qi Wang, N. Cho, Yi Wang, Zhenlang Lin   +7 more
semanticscholar   +1 more source

Naringenin and Atherosclerosis: A Review of Literature

Current Pharmaceutical Biotechnology, 2015
Atherosclerosis is a multifactorial disease mainly caused by deposition of low-density lipoprotein (LD) cholesterol in macrophages of arterial walls. Atherosclerosis leads to heart attacks as well as stroke. Epidemiological studies showed that there is an inverse correlation between fruit and vegetable consumption and the risk of atherosclerosis.
Orhan, Ilkay, Nabavi, Seyed, Daglia, Maria, TENORE, GIAN CARLO, Mansouri, Kowsar, Nabavi, Seyed   +5 more
openaire   +4 more sources

Naringenin Inhibits Ferroptosis in Renal Tubular Epithelial Cells of Diabetic Nephropathy Through SIRT1/FOXO3a Signaling Pathway

Drug development research (Print)
Naringenin has the potential to regulate ferroptosis and mitigate renal damage in diabetic nephropathy (DN). However, it remains unclear whether the naringenin's effects in DN are linked to its ability to regulate ferroptosis. This study investigated the
Yi Zhou, Tianchi Hu, Huarong Zeng, Lin Lin, Huan Xie, Rong Lin, Meng Huang   +6 more
semanticscholar   +1 more source

Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole‐induced polycystic ovary syndrome in the Sprague Dawley rats

Phytotherapy Research, 2023
Polycystic ovary syndrome (PCOS) is most common in women of reproductive age, giving rise to androgen excess and anovulation, leading to infertility and non‐reproductive complications.
Rumaisa Rashid, Rupal Tripathi, Akanksha Singh, Sudarsan Sarkar, Ajay K. Kawale, G. N. Bader, Satish Gupta, Rakesh Kumar Gupta, R. Jha   +8 more
semanticscholar   +1 more source

Microbial transformation of naringenin derivatives

Archives of Pharmacal Research, 2017
Microbial transformations of (±)-7-O-prenylnaringenin (7-PN, 1) and (±)-7-O-allylnaringenin (7-AN, 2) have isolated four metabolites (3-6). Structures of these novel compounds were identified as 5,4'-dihydroxy-7-O-[(2E)-4-hydroxy-3-methyl-2-buten-1-yl]flavanone (3), 5,4'-dihydroxy-7-O-(2,3-dihdroxy-3-methylbutyl)flavanone (4), 5,4'-dihydroxy-7-O-(2,3 ...
Yina, Xiao, Ik-Soo, Lee
openaire   +2 more sources

Improvement of Chalcone Synthase Activity and High-Efficiency Fermentative Production of (2S)-Naringenin via In Vivo Biosensor-Guided Directed Evolution.

ACS Synthetic Biology
Chalcone synthase (CHS) catalyzes the rate-limiting step of (2S)-naringenin (the essential flavonoid skeleton) biosynthesis. Improving the activity of the CHS by protein engineering enhances (2S)-naringenin production by microbial fermentation and can ...
Yingjia Tong, Ning Li, Shenghu Zhou, Liang Zhang, Sha Xu, Jingwen Zhou   +5 more
semanticscholar   +1 more source

Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
PURPOSE To evaluate the effect of naringenin on improving PCOS and explore the mechanism. METHODS Firstly, we carried out differential gene expression analysis from transcriptome sequencing data of human oocyte to screen the KEGG pathway, then the PCOS-
Yan-xiang Wu, Xiuyan Yang, Bao-sheng Han, Yuan-yuan Hu, Tian An, Bo-han Lv, Juan Lian, Tingting Wang, Xue Bao, Lin Gao, G. Jiang   +10 more
semanticscholar   +1 more source

Solubilities of Naringin and Naringenin in Different Solvents and Dissociation Constants of Naringenin

Journal of Chemical & Engineering Data, 2015
The solubilities of naringin and naringenin in methanol, isopropanol, ethyl acetate, petroleum ether, n-butanol, and hexane were measured by using UV spectrophotometric methods at the maximum absorption wavelength of (283 and 372) nm from (288.15 to 328.15) K.
Liqin Zhang, Li Song, Peipei Zhang, Tingting Liu, Li Zhou, Guangde Yang, Rong Lin, Jiye Zhang   +7 more
openaire   +1 more source

The role of the natural compound naringenin in AMPK-mitochondria modulation and colorectal cancer inhibition.

Phytomedicine
BACKGROUND Although AMP-activated protein kinase (AMPK) has been extensively studied in cellular processes, the understanding of its substrates, downstream functions, contributions to cell fate and colorectal cancer (CRC) progression remains incomplete.
Dan Wang, Yue Zhou, Li Hua, Meichun Hu, Ni Zhu, Yifei Liu, Yanhong Zhou   +6 more
semanticscholar   +1 more source

Antiandrogenic Activity of the Phytoestrogens Naringenin, 6-(1,1-Dimethylallyl)naringenin and 8-Prenylnaringenin

Planta Medica, 2003
Naturally occurring naringenin derivatives, known for their estrogenic activity, were tested in two independent (anti-)androgen screening assays. Using a yeast-based androgen receptor assay relatively strong antiandrogen activities were demonstrated for 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin, while the parent compound naringenin did not
Oliver, Zierau, Colm, Morrissey, R William G, Watson, Pia, Schwab, Susanne, Kolba, Peter, Metz, Günter, Vollmer   +6 more
openaire   +2 more sources