Results 41 to 50 of about 1,082,029 (301)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

"Looking behind the veil": invisible corporate intangibles, stories, structure and the contextual information content of disclosure [PDF]

open access: yes, 2009
Purpose – This paper aims to use a grounded theory approach to reveal that corporate private disclosure content has structure and this is critical in making "invisible" intangibles in corporate value creation visible to capital market participants ...
Holland, J.
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Inferring Interpersonal Relations in Narrative Summaries

open access: yes, 2015
Characterizing relationships between people is fundamental for the understanding of narratives. In this work, we address the problem of inferring the polarity of relationships between people in narrative summaries.
Chaturvedi, Snigdha   +2 more
core   +1 more source

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

The effects of a narrative structure and English proficiency on university students’ speaking performance: Pausing patterns

open access: yesIndonesian Journal of Applied Linguistics, 2018
Literature has shown that a narrative structure and narrative complexity factor into the speaking performance of L2 learners, especially those of lower-proficiency level of various L1 backgrounds (e.g., see Tavakoli Foster, 2008).
Eri Kurniawan, Eka Parwati
doaj   +1 more source

Global coherence, narrative structure, and expectations of relevance [PDF]

open access: yes, 2002
A topic for both literary studies and discourse analysis is the global structure of texts. Studies of global text structure have largely been focused on narrative structure, where a major strand of research has been devoted to the role which grounding ...
Unger, Dr. Christoph
core  

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati   +10 more
wiley   +1 more source

Focus or narrative constructions? : Morphosyntactically marked focus constructions in some Gur and Kwa languages [PDF]

open access: yes, 2009
0. Introduction 1. Observations concerning the structure of morphosyntactically marked focus constructions 1.1 First observation: SF vs. NSF asymmetry 1.2 Second observation: NSF-NAR parallelism 1.3 Affirmative ex-situ focus constructions (SF, NSF), and ...
Fiedler, Ines, Schwarz, Anne
core  

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang   +10 more
wiley   +1 more source

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