Results 31 to 40 of about 5,659,205 (204)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Using the quantum probability ranking principle to rank interdependent documents [PDF]

, 2010
A known limitation of the Probability Ranking Principle (PRP) is that it does not cater for dependence between documents. Recently, the Quantum Probability Ranking Principle (QPRP) has been proposed, which implicitly captures dependencies between ...
Azzopardi, L., Leif Azzopardi, Guido Zuccon, Zuccon, G., Azzopardi, Leif, Zuccon, Guido   +5 more
core   +2 more sources

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Radially Symmetric Solution for Fractional Laplacian Systems with Different Negative Powers

Fractal and Fractional, 2022
By developing the direct method of moving planes, we study the radial symmetry of nonnegative solutions for a fractional Laplacian system with different negative powers: (−Δ)α2u(x)+u−γ(x)+v−q(x)=0,x∈RN, (−Δ)β2v(x)+v−σ(x)+u−p(x)=0,x∈RN, u(x)≳|x|a,v(x)≳|x ...
Haiyong Xu, Bashir Ahmad, Guotao Wang, Lihong Zhang   +3 more
doaj   +1 more source

Patients improve, patterns persist: longitudinal stability of RA joint involvement patterns

Arthritis Care &Research, Accepted Article.
Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen, Yasuo Nagafuchi, Kristina Lend, Seyam Alemyar, Herman Kasper Glas, Gerdur Gröndal, Bjorn Gudbjornsson, Espen A. Haavardsholm, Kim Hørslev Petersen, Jon Lampa, Merete Lund Hetland, Dan Nordström, Mike Nurmohamed, Mikkel Østergaard, Anna Rudin, Marte Schrumpf Heiberg, Tuulikki Sokka‐Isler, Till Uhlig, Josien Veris‐van Dieren, Ronald van Vollenhoven, Tom Huizinga, Marcel JT Reinders, Sytske Anne Bergstra, Erik van den Akker, Rachel Knevel   +24 more
wiley   +1 more source

Phytophagous beetles (Coleoptera: Chrysomelidae and Curculionoidea), protected and recommended for protection in the regions of the Middle Volga and the Urals

Nature Conservation Research: Заповедная наука, 2020
Using results of long-term studies of the two largest groups of phytophagous beetles in the East of the Russian Plain and the Urals, we carried out a critical overview of species included in Red Data Books of eight regions of the Russian Federation.
Sergei V. Dedyukhin
doaj   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Mixed Land use Pattern in Deteriorated and Inefficient Neighborhoods of Region Eighteen of Tehran and its Role in Sustainable Neighborhood Regeneration

جغرافیا و پایداری محیط, 2021
Urban development based on the mixed land use is a new approach not only to regulate and make optimal use of physical space but also achieve sustainability, especially in the process of regenerating deteriorated and inefficient urban area of ...
Mojtaba Roustaei, Ahmad Pour Ahmad, Nafiseh Marsousi, esmaeil ali akbari   +3 more
doaj   +1 more source

Entropy‐Driven Design of Low‐Melting‐Point Alloys via Compositionally Complex Strategy

Advanced Engineering Materials, EarlyView.
Conventional low‐melting‐point alloys (LMPAs) are limited by a narrow compositional space and inherent property trade‐offs. This review presents an entropy‐driven design strategy that overcomes these limitations, ushering in a new class of low‐melting‐point compositionally complex alloys (LMCCAs).
Yinghui Shang, Jianxiang Zhao, Zhaoqi Chen, Hao Gong, Yinsen Yan, Junlei Tao, Yong Yang   +6 more
wiley   +1 more source

The location and kinematics of the emission line regions in Active Galactic Nuclei [PDF]

, 2008
This thesis contains the results from a study of the optical emission lines of various samples of active galactic nuclei (AGN). We have used three separate techniques to determine the precise kinematics and the relative location of the emission line ...
Mullaney, J R, Mullaney, J.R.
core