Results 151 to 160 of about 2,438,339 (329)

Puerarin transport across a Calu-3 cell monolayer – an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol

Drug Design, Development and Therapy, 2016
Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Zhi-Hao Tian, Chang Yang, Hui-Chao Wu, Zhen Wang School of Chinese Materia Medica, Beijing University of Chinese Medicine, Chaoyang District, Beijing, People’s Republic of China Abstract: Nasal ...
Zhang L, Du SY, Lu Y, Liu C, Tian ZH, Yang C, Wu HC, Wang Z   +7 more
doaj  

Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinson's disease.

Journal of Controlled Release, 2020
E. R. de Oliveira Junior, E. Truzzi, L. Ferraro, M. Fogagnolo, B. Pavan, S. Beggiato, C. Rustichelli, Eleonora Maretti, E. Lima, E. Leo, A. Dalpiaz   +10 more
semanticscholar   +1 more source

Nasal Delivery to the Brain: Harnessing Nanoparticles for Effective Drug Transport

Pharmaceutics
The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome the challenges associated with conventional drug administration for central nervous system disorders. This emerging field is driven by the anatomical advantages of the
Shivani Gandhi, D. Shastri, Jigar N. Shah, Anroop B Nair, S. Jacob   +4 more
semanticscholar   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Formaldehyde exposure induces histopathological and morphometric changes in the rat testis [PDF]

, 2007
Formaldehyde is a chemical which is traditionally used for fixing cadavers and routine histopathology techniques. It is vaponsed during the dissection and practical study of a cadaver.
Azarhoush, R., Davarian, A., Fazeli, S.A., Ghafari, S., Gharravi, A.M., Golalipour, M.J.   +5 more
core  

Administration of Ligilactobacillus salivarius CECT 30632 to elderly during the COVID-19 pandemic: Nasal and fecal metataxonomic analysis and fatty acid profiling [PDF]

, 2022
Marta Mozota, Irma Castro, Natalia Gómez‐Torres, Rebeca Arroyo, Isabel Gutiérrez‐Díaz, Susana Delgado, Juan M. Rodrı́guez, Claudio Alba   +7 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Adjuvants : an essential component of neisseria vaccines [PDF]

, 2009
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis ...
Acevedo, R., Balbao, J., Cabrera, O., Cuello, M., del Campo, J., Ferro, Valerie A., Gonzales, E., Romeu, B., Zayas, C.   +8 more
core  

Cytokine expression after the topical administration of substance P to human nasal mucosa. The role of substance P in nasal allergy. [PDF]

, 1993
Y. Okamoto, Koji Shirotori, K Kudo, Kazuo Ishikawa, Eiko Ito, Kiyoshi Togawa, Ichiro Saito   +6 more
openalex   +1 more source

Computational study of the impact of nasal vestibule anatomy on nasal drug administration with nasal spray

International Journal of Pharmaceutics
The nasal airway comprises a complex network of passages and chambers and plays an important role in regulating the respiratory system's functions. The nasal vestibule is the first chamber of the nasal airway. While variations in nasal vestibule geometries are known to exist between humans, details of their implications on how they may affect the ...
Zhiwei Shen, Jingliang Dong, Xinyu Cai, Hanieh Gholizadeh, Hak-Kim Chan, Ann Lee, Agisilaos Kourmatzis, Shaokoon Cheng   +7 more
openaire   +2 more sources