Results 281 to 290 of about 2,438,339 (329)

Withanolide a penetrates brain via intra-nasal administration and exerts neuroprotection in cerebral ischemia reperfusion injury in mice

Xenobiotica; the fate of foreign compounds in biological systems, 2019
1. Withanolide A (WA), a major constituent phytochemical of the Ayurvedic herb Withania somnifera reportedly combats neurodegeneration in Alzheimer’s disease and Parkinson’s disease.
S. Mukherjee, Gaurav Kumar, R. Patnaik
semanticscholar   +1 more source

Infant Oxygen Administration by Modified Nasal Cannula

Clinical Pediatrics, 1984
In both pediatric and neonatal intensive care settings, and occasionally at home, there exists the need to deliver chronic low dose oxygen therapy to small, uncooperative patients. To be effective, a method of oxygen delivery must be both reliable and comfortable, and, at the same time, inexpensive and safe.
T H, Kloor, D, Carbajal
openaire   +2 more sources

Nasal administration of low molecular weight heparin

Journal of Pharmaceutical Sciences, 2002
The main objective of this study was to determine if the systemic absorption of therapeutic amounts of heparin was possible following nasal administration. Sprague-Dawley rats received nosedrops containing a low molecular weight heparin (LMWH) or unfractionated heparin (UFH) formulated with or without tetradecylmaltoside (TDM).
John, Arnold, Fakhrul, Ahsan, Elias, Meezan, Dennis J, Pillion   +3 more
openaire   +2 more sources

Emulsion formulations of testosterone for nasal administration

Journal of Microencapsulation, 1998
The nasal route has received a great deal of attention due to the many advantages of nasal delivery over parenteral administration. The male sex hormone testosterone is ineffective when administered orally due to its gut wall and first-pass metabolism.
K T, Ko, T E, Needham, H, Zia
openaire   +2 more sources

NASAL CATHETER ADMINISTRATION OF OXYGEN

Journal of the American Medical Association, 1934
The clinical administration of oxygen is now being employed in many disorders and is being used in the home as well as in the hospital. This has been rendered possible through the improved availability of oxygen and the development of simplified equipment for its administration. In general, it is considered that the inhaled air must contain from 35 to
M. HERBERT BARKER, D. M. PARKER, GEORGE WASSEL   +2 more
openaire   +1 more source

Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs

Journal of Veterinary Pharmacology and Therapeutics, 2011
Musulin, S. E., Mariani, C. L., Papich, M. G. Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs.J. vet. Pharmacol. Therap.34, 17–24.The standard of care for emergency therapy of seizures in veterinary patients is intravenous (i.v.) administration of benzodiazepines, although rectal administration of diazepam is often ...
S E, Musulin, C L, Mariani, M G, Papich
openaire   +2 more sources

A new nanovesicular system for nasal drug administration

International Journal of Pharmaceutics, 2020
The goal of this work was to study the characteristics of a new phospholipid nanovesicular carrier for nasal administration of drugs. Multilamellar vesicles were visualized by electron microscopy, and their mean distribution size of 200 nm was evaluated by DLS. Measured pH and viscosity values were found adequate for a nasal delivery carrier.
Elka, Touitou, Shaher, Duchi, Hiba, Natsheh   +2 more
openaire   +2 more sources

Nasal Administration of IgA to Individuals with Hypogammaglobulinemia

Scandinavian Journal of Infectious Diseases, 1993
Many immunodeficient patients constantly carry non-typable Hemophilus influenzae (NTHI) in the nasopharynx, despite seemingly adequate antibiotic therapy. We have studied the effect of nasal administration of IgA on nasopharyngeal colonization in 5 patients with hypogammaglobulinemia, with a productive cough, especially in the mornings, who were ...
K, Lindberg, A, Samuelson, B, Rynnel-Dagöö, E, Smith, L, Hammarström   +4 more
openaire   +2 more sources

Nasal Administration of Vaccines

2014
Nasal administration of vaccines is an interesting route of delivery as it targets one of the mucosal surfaces naturally being in contact with many airborne pathogens. For this reason, the nasal mucosa has a dense network of immunocompetent cells which can be utilised for vaccination.
openaire   +1 more source

Mucoadhesive chitosan microspheres of carvedilol for nasal administration

Journal of Drug Targeting, 2010
The aim of the present study was to develop and characterize chitosan mucoadhesive microspheres of carvedilol (CRV) for nasal delivery to improve bioavailability for treatment of hypertension and angina pectoris. The microspheres were prepared by emulsification-cross-linking method and evaluated for size, shape, entrapment efficiency (EE), in vitro ...
Sanjay, Patil, Anil, Babbar, Rashi, Mathur, Anil, Mishra, Krutika, Sawant   +4 more
openaire   +2 more sources