Results 281 to 290 of about 2,087,592 (382)

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

open access: yesInternational Journal of Cancer, EarlyView.
What's New? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman   +15 more
wiley   +1 more source

Distribution and Antimicrobial Resistance of Pathogenic Bacteria in Patients With Sternal Osteomyelitis

open access: yesiLABMED, EarlyView.
This study conducted a retrospective analysis of microbiological culture results and antimicrobial resistance patterns in patients with sternal osteomyelitis at a tertiary medical center. The primary pathogens causing sternal osteomyelitis were gram‐positive bacteria. Infections with multidrug‐resistant organisms were also relatively common among these
Yumin Yang   +5 more
wiley   +1 more source

Quantitative Mapping of Fibrotic Tissue Mechanics via Brillouin Spectroscopy

open access: yesJournal of Biophotonics, EarlyView.
Brillouin spectroscopy distinguishes fibrotic from healthy tissue based on localized stiffness changes and enables real‐time monitoring of dynamic alterations in viscoelastic properties during fibrogenesis. ABSTRACT Fibrosis is a pathological scarring process that disrupts tissue architecture, and is characterized by excessive extracellular matrix (ECM)
Vsevolod Cheburkanov   +3 more
wiley   +1 more source

Efficacy of Fetal Ear Length as a Prenatal Marker of Chromosomal Anomalies: A Prospective, Multicenter Cohort Study in a Southern European Population

open access: yesJournal of Clinical Ultrasound, EarlyView.
Fetal ear length (FEL) correlates with gestational age and may help detect chromosomal anomalies. This study developed a nomogram for a Southern European population, showing high measurement reliability. While FEL ≤ 5th percentile increased anomaly risk, its moderate sensitivity and specificity limit clinical utility.
Elisabet Baldrich   +6 more
wiley   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

open access: yesJournal of Orthopaedic Research, EarlyView.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon   +9 more
wiley   +1 more source

Bone CT Evaluation of Nasal Cavity of Acromegalics -Its Morphological and Surgical Implication in Comparison to Non-Acromegalics

open access: bronze, 2000
Naokatsu Saeki   +9 more
openalex   +2 more sources

Drugs in focus: Budesonide and its role in paediatric gastrointestinal disorders

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Budesonide is a glucocorticoid with strong topical anti‐inflammatory properties and minimal systemic effects due to extensive first‐pass hepatic metabolism. It is designed for targeted delivery within the gastrointestinal (GI) tract and is available in oral and rectal formulations.
Sohail Aziz   +11 more
wiley   +1 more source

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