Results 171 to 180 of about 50,980 (286)

Exercise‐induced dynamic hyperinflation in chronic obstructive pulmonary disease

open access: yesExperimental Physiology, EarlyView.
Abstract Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease caused by inhalation of noxious particles, most commonly cigarette smoking. The consequent changes in airways, lung parenchyma and pulmonary vasculature lead to increased resistive, elastic and threshold loads and impaired capacity of the respiratory muscle pump. COPD
Rebecca F. D'Cruz   +2 more
wiley   +1 more source

The hypoxic ventilatory response and arousal burden predict the magnitude of ventilatory long‐term facilitation in humans with obstructive sleep apnoea

open access: yesExperimental Physiology, EarlyView.
Abstract The magnitude of progressive augmentation (PA) and ventilatory long‐term facilitation (vLTF) are two forms of respiratory plasticity that are enhanced in some humans with obstructive sleep apnoea (OSA). This response might be linked to repeated nocturnal exposure to intermittent hypoxia or other traits connected to OSA.
Jason H. Mateika   +3 more
wiley   +1 more source

Neuromuscular and neuromechanical assessments of respiratory performance in the mdx mouse model of Duchenne muscular dystrophy across the natural history of disease

open access: yesExperimental Physiology, EarlyView.
Abstract Duchenne muscular dystrophy (DMD) is a severe life‐limiting X‐linked neuromuscular disorder characterised by progressive skeletal muscle degeneration and respiratory failure. The mdx mouse, lacking dystrophin, is the most widely used preclinical model of DMD, yet the trajectory of respiratory dysfunction in this model remains incompletely ...
Michael N. Maxwell   +4 more
wiley   +1 more source

Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32‐Week Randomized Phase 1b Multiple Ascending‐Dose Trial

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 782-790, March 2026.
Verekitug, a novel, high‐affinity, fully human monoclonal antibody targeting thymic stromal lymphopoietin receptor (TSLPR), is in development as a potential treatment for severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD).
Dave Singh   +9 more
wiley   +1 more source

Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real‐Time Chemical Analysis

open access: yesMass Spectrometry Reviews, Volume 45, Issue 2, Page 392-428, March/April 2026.
ABSTRACT In the 1980s, researchers discovered the remarkable ability of electrospray plumes to effectively ionize gas‐phase molecules via secondary ionization. Around 20 years later—coinciding with the ambient mass spectrometry revolution—secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI) coupled to mass spectrometry
Xin Luo   +5 more
wiley   +1 more source

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