Results 131 to 140 of about 705,495 (373)

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang   +17 more
wiley   +1 more source

Korelasi Antara Visual Analogue Scale (VAS) dan Peak Nasal Inspiratory Flow (PNIF) Sebelum dan Sesudah Septoplasti

open access: yesMajalah Kedokteran Bandung, 2015
Septal deviation is a frequently found state that varies from minor without interferences to severe cases of septal deviation that can cause nasal obstruction.
Augustien Yuliet Tamus   +2 more
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

open access: yesAdvanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

A Scoping Review of Surgical Interventions for Nasal Valve Obstruction in Facial Paralysis

open access: yesLaryngoscope Investigative Otolaryngology
Objective The main objective of this scoping review was to identify various surgical techniques used to treat nasal airway obstruction Caused by facial paralysis and summarize available outcome data for these techniques.
Raj Patel   +4 more
doaj   +1 more source

Heterosynaptic Memtransistors Based on Switching Operation Mechanism Using Designed Organic/Inorganic Heterostructures for Neuromorphic Electronics

open access: yesAdvanced Science, EarlyView.
Heteroysynaptic memtransistors are fabricated using a combination of π‐conjugated organic semiconductor TCTA and TMDC MoS2 heterostructure with bottom‐contact architecture. Non‐volatile heterosynaptic and homosynaptic functions such as long‐term plasticity and spike‐timing‐dependent plasticity are emulated by drain and gate pulses based on conduction ...
Taek Joon Kim   +5 more
wiley   +1 more source

Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots

open access: yesAdvanced Science, EarlyView.
Crustacean exoskeletons, repurposed from food waste, are engineered into sustainable bending actuators combining biotic structure with synthetic control. The augmented exoskeletons achieve rapid and robust motion with lightweight body and can be used as part of robotic manipulators, grippers and swimmers.
Sareum Kim, Kieran Gilday, Josie Hughes
wiley   +1 more source

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