Results 71 to 80 of about 9,405 (123)
MiR‐221‐3p Attenuates IL‐33‐Induced Mast Cell Cytokine Expression by Targeting KIT
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)‐33 stimulation. MiR‐221 is reported to be an important regulator of MCs, and miR‐221‐3p can be expressed in CRSwNP. However, the role of miR‐221‐3p in CRSwNP is unclear. Methods Ethmoid tissues
Ruowu Liu +11 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background The pathogenesis of inflammation in eosinophilic chronic rhinosinusitis (ECRS) and non‐eosinophilic chronic rhinosinusitis (NECRS) remains poorly understood. This study aimed to assess immune cell infiltration within the sinonasal microenvironment in these conditions.
Katarzyna Czerwaty +5 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Particulate matter ⩽2.5 µm in diameter (PM2.5) and its role in chronic rhinosinusitis (CRS) pathogenesis have gained heightened attention. We previously demonstrated that PM2.5 exposure may bias the nasal mucosa in CRS toward a Type 2 inflammatory pathway.
Rory J. Lubner +5 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin +9 more
wiley +1 more source
Global Challenges, Volume 7, Issue 1, January 2023., 2023 Bibliometric and systematic analysis shows research from 1990 to 2020 reveals the versatility of magnetite nanoparticles and their evolving usage in a number of fields. Initially focusing on the environmental and industrial applications, to the biomedical applications. However, recent research highlights their toxicity and potential detrimental effects
Charlotte L. Fleming +3 more
wiley +1 more source
An adjoint-based approach for the surgical correction of nasal septal deviations [PDF]
arXivDeviations of the septal wall are widespread anatomic anomalies of the human nose; they vary significantly in shape and location, and often cause the obstruction of the nasal airways. When severe, septal deviations need to be surgically corrected by ear-nose-throat (ENT) specialists.
arxiv
Angewandte Chemie International Edition, EarlyView.Using a novel on‐chip synthesis technology, microarrays of peptidoglycan fragments were generated comprising 864 variants derived from Gram‐positive and Gram‐negative bacteria. These were used to map monoclonal antibody specificity and to screen samples from patients with the autoimmune disease epidermolysis bullosa, revealing distinct antibody ...
Alexandra Tsouka +12 more
wiley +1 more source
Human Brain Mapping, Volume 44, Issue 1, Page 245-257, January 2023., 2023 In older adults who experienced the death of a partner, higher prolonged grief symptoms were associated with less anticorrelation between retrosplenial default network and cingulo‐opercular networks during resting state, and more dwell time in a dynamic functional connectivity state involving positive correlations between large‐scale brain networks ...
Saren H. Seeley +3 more
wiley +1 more source
Cross-organ Deployment of EOS Detection AI without Retraining: Feasibility and Limitation [PDF]
arXivChronic rhinosinusitis (CRS) is characterized by persistent inflammation in the paranasal sinuses, leading to typical symptoms of nasal congestion, facial pressure, olfactory dysfunction, and discolored nasal drainage, which can significantly impact quality-of-life. Eosinophils (Eos), a crucial component in the mucosal immune response, have been linked
arxiv