Results 141 to 150 of about 222,937 (263)

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Serum Biomarkers as Predictors of Recurrence in Chronic Rhinosinusitis with Nasal Polyps. [PDF]

Medicina (Kaunas)
Florean MD, Mare C, Gâta A, Trombitaș VE, Budișan L, Zanoaga O, Berindan-Neagoe I, Stelea CG, Roman A, Albu S.   +9 more
europepmc   +1 more source

Diagnostic Delay in Eosinophilic Granulomatosis With Polyangiitis: Clinical Predictors and Implications for Earlier Recognition

Allergy, EarlyView.
This study aimed to assess diagnostic delay among patients with eosinophilic granulomatosis with polyangiitis (EGPA) and identify clinical characteristics associated with delayed recognition. EGPA diagnosis was delayed by nearly five years from symptom onset in this single‐center cohort.
Vani Mulkareddy, Kalena Liu, Shreya Mandloi, Kelsey Limage, Samuel R. Shing, Gurston G. Nyquist, Jessica Most, David Kennedy, Elina Toskala, Damaris Pena‐Evertz   +9 more
wiley   +1 more source

Rethinking Monospecific Antibody Therapy in Chronic Rhinosinusitis with Nasal Polyps: Dual- and Multispecific Antibodies. [PDF]

Clin Rev Allergy Immunol
Dai Y, Guo T, Shi M, Wang D, Wang M.
europepmc   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Biologics in pediatric chronic rhinosinusitis with nasal polyps: A systematic review of efficacy and safety. [PDF]

Pediatr Allergy Immunol
Loperfido A, Anzivino R, Galletti C, Moffa A, Stivalini D, La Mantia I, De Corso E.   +6 more
europepmc   +1 more source

Complement–Eosinophil Crosstalk Links Complement Activation to Fibrin Deposition in Eosinophilic Chronic Rhinosinusitis

Allergy, EarlyView.
Ryo Hasegawa, Shigeharu Ueki, Misaki Arima, Shohei Nishiyama, Keinosuke Hizuka, Kohei Tatsumi, Ayako Sawai, Anna Shimizu, Yuki Sonoda, Eiichi Kato, Masanori Kidoguchi, Masafumi Sakashita, Yohei Sato, Atsushi Kato, Bruce K. Tan, Robert C. Kern, Robert P. Schleimer, Shigeharu Fujieda, Yoshimasa Imoto   +18 more
wiley   +1 more source

Clinical Trial: Dupilumab Improves Eosinophilic Oesophagitis Outcomes Versus Placebo Regardless of Comorbidities or Treatment History in a Randomised Clinical Trial

Alimentary Pharmacology &Therapeutics, EarlyView.
Dupilumab improved all histological, symptomatic, and endoscopic outcomes assessed at Week 24 versus placebo in patients with eosinophilic oesophagitis, regardless of demographics, disease characteristics, treatment history, or type 2 inflammatory disease comorbidities.
Evan S. Dellon, Marc E. Rothenberg, Jonathan M. Spergel, Albert J. Bredenoord, Antonella Cianferoni, Changming Xia, Margee Louisias, Allen Radin   +7 more
wiley   +1 more source

Survey of Local and Systemic Corticosteroids Use in Adults with Chronic Rhinosinusitis with Nasal Polyps in Chile. [PDF]

J Inflamm Res
Navarro-Aguilar D, Valdés CJ, Seguí G, Daszenies C, Niklitschek E, Oberreuter G, León AS, Rojas-Lechuga MJ, Moreno-Luna R, Stivalini D, Gambacorta V, De Corso E.   +11 more
europepmc   +1 more source

Ocular Surface Findings in Patients with Surgery-Indicated Chronic Rhinosinusitis with Nasal Polyps: A Retrospective Study. [PDF]

Diagnostics (Basel)
Abdioğlu Fazlı E, Köse B, Kurutaş ÖK, Bahadır O.   +3 more
europepmc   +1 more source