Results 141 to 150 of about 58,092 (289)

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

A Case for Anti‐IgE Vaccination

Allergy, EarlyView.
ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff, Zahra Gharailoo, Monique Vogel, Martin F. Bachmann   +3 more
wiley   +1 more source

The Future of ORLHNS and Associated Specialties Series: The future of rhinology, anterior skull base and facial plastic surgery [PDF]

, 2002
Lund, VJ, Rowe-Jones, JM
core   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Advance in biologics for chronic rhinosinusitis with nasal polyps. [PDF]

Front Allergy
Di Y, Zeng R, Huang L, Wu Y, Wu Q.
europepmc   +1 more source

Happiness and Smell: Overlooked Factors in Endoscopic Sinus Surgery?

Clinical Otolaryngology, EarlyView.
ABSTRACT Objective This study investigates the impact of functional endoscopic sinus surgery (FESS) on happiness levels in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and examines the factors influencing postoperative happiness. Methods This study included 55 patients (34 males, 21 females; mean age, 41.2 ± 14.7 years) who underwent
Tuğba Tulacı, Omer Hizli, Hasan Çanakçı, Mustafa Utku Akbaş, Kamil Gökçe Tulacı   +4 more
wiley   +1 more source

The exploration of immunological landscape and drug targets in chronic rhinosinusitis with nasal polyps. [PDF]

World Allergy Organ J
Zhang R, Fu P, Tian H.
europepmc   +1 more source

Individual and Societal Economic Burden of Chronic Rhinosinusitis with or Without Nasal Polyps. [PDF]

Med Sci (Basel)
Håkansson KEJ, Andersen SAW, Løkke A, Hilberg O, Ibsen R, Ulrik CS, Backer V.   +6 more
europepmc   +1 more source

Efficacy and Safety of Anti‐IL‐4Rα Stapokibart in Elderly Patients With Moderate‐To‐Severe Atopic Dermatitis

International Journal of Dermatology, EarlyView.
ABSTRACT Background Elderly patients with moderate‐to‐severe atopic dermatitis (AD) often exhibit more heterogeneous inflammatory profiles compared with younger adults. To evaluate the efficacy and safety of stapokibart, an anti‐interleukin‐4 receptor α subunit (IL‐4Rα) monoclonal antibody, in different age subgroups.
Yan Zhao, Litao Zhang, Liming Wu, Bin Yang, Jinyan Wang, Yumei Li, Qingchun Diao, Jingyi Li, Qing Sun, Xiaohong Zhu, Xiaoyong Man, Lihua Wang, Yanyan Feng, Tao Cai, Huiming Zeng, Linfeng Li, Jianyun Lu, Hong Ren, Fuqiu Li, Qianjin Lu, Xiaohua Tao, Rong Xiao, Chao Ji, Jing Sun, Yanping Qiu, Bo Chen, Jianzhong Zhang   +26 more
wiley   +1 more source

Identification of hypoxia-related gene signatures and molecular subtypes in chronic rhinosinusitis with nasal polyps. [PDF]

Braz J Otorhinolaryngol
Song L, Zhou S, Wang L, Lai J, Tan S, Yao C, Yu S.   +6 more
europepmc   +1 more source