Results 81 to 90 of about 62,516 (342)

Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32‐Week Randomized Phase 1b Multiple Ascending‐Dose Trial

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Verekitug, a novel, high‐affinity, fully human monoclonal antibody targeting thymic stromal lymphopoietin receptor (TSLPR), is in development as a potential treatment for severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD).
Dave Singh   +9 more
wiley   +1 more source

Nasal Dermoplasty for Recurrent Polyps in a Patient with Churg-Strauss Syndrome

open access: yesCase Reports in Otolaryngology, 2015
Nasal dermoplasty for recurrent polyps (NDRP) is a new technique for the surgical treatment of this condition. Churg-Strauss syndrome is characterized by the presence of nasal polyps with a great tendency for relapse after surgical or pharmaceutical ...
George Anastasopoulos   +3 more
doaj   +1 more source

Schwannoma of the nasal septum-a case report [PDF]

open access: yes, 2012
Schwannomas of the nasal cavity and paranasal sinuses are very rare. We report the case of a50-year-old woman with a schwannoma arising from the nasal septum.
Felix, Vinod   +2 more
core   +1 more source

Staphylococcus aureus controls interleukin-5 release in upper airway inflammation [PDF]

open access: yes, 2018
Staphylococcus aureus is a frequent colonizer of the upper airways in chronic rhinosinusitis with nasal polyps, but also resides intramucosally, it has been shown that secreted staphylococcal proteins such as enterotoxins and serine proteases induce the ...
Bachert, Claus   +11 more
core   +2 more sources

Dupilumab as an effective therapy for eosinophilic esophagitis in pediatric patients weighing less than 15 kilograms

open access: yesJPGN Reports, EarlyView.
Abstract Objectives Eosinophilic esophagitis (EoE) is a type 2 cytokine‐mediated chronic inflammatory condition leading to esophageal dysfunction. Dupilumab blocks IL‐4 and IL‐13 signaling, which are key inflammatory mediators in EoE and other allergic disorders.
Sindhura Kasturi   +6 more
wiley   +1 more source

Atopic Comorbidities Associated With Chronic Spontaneous Urticaria: A Case‐Control Analysis of the All of Us Research Program

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Chronic spontaneous urticaria (CSU) is a mast cell‐driven condition defined by recurrent wheals and/or angioedema lasting over 6 weeks without an identifiable trigger. Though CSU is known to co‐occur with atopic diseases and share Th2‐dominant immunologic pathways, prior studies have not adequately addressed these relationships in ...
Julian A. Cortes   +4 more
wiley   +1 more source

Fungi as Causative Agents of Nasal Polyps in Tehran, Iran [PDF]

open access: yesIranian Journal of Public Health, 2006
Nasal polyposis is an inflammatory condition of unknown etiology that involves nasal and sinus mucous membrane. These polyps can impair a person’s quality of life by nasal obstruction, recurrent sinusitis, persistent postnasal drainage, hyposmia, anosmia,
P Kordbacheh   +4 more
doaj   +2 more sources

Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps

open access: yesRespiratory Research, 2009
Background Decreased infiltration of Foxp3+ T regulatory cell (Treg) is considered to be critical for the Th1/Th2 dysregulation of nasal polyps, while the cellular mechanism underlying Foxp3+ Treg insufficiency is currently not well defined.
Shi Jianbo   +8 more
doaj   +1 more source

Linking Complement C3 and B Cells in Nasal Polyposis

open access: yesJournal of Immunology Research, 2020
Nasal polyposis often is characterized by a persistent inflammation of the sinonasal mucosa, disease recurrence after medical or surgical intervention, and asthma comorbidity.
Ulrike Werner   +7 more
doaj   +1 more source

Different types of intranasal steroids for chronic rhinosinusitis [PDF]

open access: yes, 2015
BACKGROUND: This review is one of six looking at the primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is common and is characterised by inflammation of the lining of the nose and paranasal sinuses leading
Burton, MJ   +5 more
core   +2 more sources

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