Results 91 to 100 of about 22,731 (179)

Five‐Grass‐Pollen Sublingual Immunotherapy Drops Are Efficacious and Well Tolerated in Adults: The RHAPSODY Phase III Trial

Allergy, EarlyView.
The RHAPSODY multinational study investigated 26 months of continuous treatment with 5‐grass‐pollen sublingual SLIT drops in adults with moderate‐to‐severe grass‐pollen‐induced allergic rhinoconjunctivitis. The primary efficacy endpoint (the average daily total combined score) showed statistically significant differences in favour of the active ...
Alain Didier, Ruta Gronskyte Juhl, Terrie Dalgaard, Antoine Chartier, Philippe Devillier   +4 more
wiley   +1 more source

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications—An EAACI Task Force Report

Allergy, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS) and asthma are prevalent conditions that often coexist. These diseases share common inflammatory mechanisms, such as T‐helper cell 2 (T2)‐high inflammation, driven by interleukin (IL)‐4, IL‐5, and IL‐13 cytokines.
Sanna Toppila‐Salmi, Sietze Reitsma, Valérie Hox, Simon Gane, Philippe Gevaert, Juan Maza‐Solano, Alma Helevä, Ida Sulku, Kaisa Santala, Iiris Kangasniemi, Ludger Klimek, Adam Chaker, Aspasia Karavelia, Michael Rudenko, Oliver Pfaar, Laura Van Gerven, Shaari Ariana, Michele Schiappoli, Marie Lundberg, Jan Hagemann, Ibon Eguíluz‐Gracia, Andre Moreira   +21 more
wiley   +1 more source

What's in the Bin? A Waste Audit of an Australian Tertiary Ear, Nose and Throat Outpatient Clinic

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Healthcare contributes 4.4% of global emissions. Climate change contributes to vector‐borne diseases, food insecurity and morbidity and mortality associated with extreme weather. Ear, nose and throat (ENT) outpatient clinics are particularly resource intensive, yet their environmental impact has not been quantified.
Cassie Dow, Daron Cope, Robert Eisenberg
wiley   +1 more source

Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium

Scientific Reports
COVID-19 remains a severe condition for many including immunocompromised individuals. There remains a need for effective measures against this and other respiratory infections, which transmit via virus-laden droplets that reach the nasal or oral mucosae.
Jeremy R. A. Paull, Carolyn A. Luscombe, Aynaz Seta, Graham P. Heery, Michael D. Bobardt, Philippe A. Gallay, Samuel Constant, Alex Castellarnau   +7 more
doaj   +1 more source

Seasonal variation in the incidence of central serous chorioretinopathy: A systematic review and meta‐analysis

Acta Ophthalmologica, EarlyView.
Abstract Central serous chorioretinopathy (CSC) is a chorioretinal disease characterised by serous subretinal fluid (SRF) in the macula, resulting in sudden central vision loss. It predominantly affects working‐age adults, particularly men aged 30 to 60 years.
I. Made Ferdiko Hutamadella, Emil Ørnberg, Mark P. Breazzano, Lasse Jørgensen Cehofski, Chui Ming Gemmy Cheung, Kristina Pfau, M. Cem Sabaner, Lorenzo Ferro Desideri, Camiel J. F. Boon, Yousif Subhi, Elon H. C. van Dijk   +10 more
wiley   +1 more source

Randomized, single‐centre, double‐blinded repeated dose investigation of safety and tolerability of ocular administrations of a novel silica eye drop product in healthy volunteers

Acta Ophthalmologica, EarlyView.
Abstract Purpose Managing ocular diseases often requires frequent eye drop administration, which can challenge patient compliance. A long‐acting eye drop technology using an amorphous synthetic silica composite was developed to address this. Our study aimed to assess the safety and tolerability of the Silica Eye Drop platform in healthy volunteers over
Aleksandra Poluianova, Marceline N. Akieh‐Pirkanniemi, Arto Hartikainen, Hanna Arstila, Kai Kaarniranta, Lasse Leino   +5 more
wiley   +1 more source

Refining the timing of Middle Pleistocene (MIS 12 to MIS 6) ice advances into northern central Europe: sedimentological analysis and single‐grain luminescence dating of glaciotectonic complexes and tunnel‐valley fills

Boreas, EarlyView.
We summarize the current state of knowledge on the age of the Middle Pleistocene ice advances into northern central Europe and provide 25 new single‐grain feldspar luminescence ages of Elsterian and Saalian glacigenic sediments to constrain the age of the ice advances and their tentative correlation with marine isotope stages/substages.
Niklas von Soest, Neda Rahimzadeh, Debra Colarossi, Falko Malis, Tobias Lauer, Wera Sander‐Beuermann, Yvonne Spychala, Christian Brandes, Runa Fälber, Sumiko Tsukamoto, Jutta Winsemann   +10 more
wiley   +1 more source

Rescue Therapy With Quad Zygoma After Failure of Full‐Arch Implant Rehabilitation: A Retrospective Study With a Mean Follow‐Up of 8 Years

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To evaluate the long‐term clinical outcomes of quad zygomatic implants (ZIs) as a rescue therapy for patients with failed full‐arch implant rehabilitation in the maxilla due to advanced peri‐implantitis. Material and Methods This was a retrospective cohort study of all patients treated with the Quad Zygoma Protocol. Primary outcomes
Shengchi Fan, Wenjie Zhou, Bilal Al‐Nawas, Eduard Valmaseda‐Castellón, Rubén Davó   +4 more
wiley   +1 more source

The Septoplasty Healthcare Monitor: An Outcome Assessment Infrastructure to Enhance the Quality and Transparency of Care

Clinical Otolaryngology, EarlyView.
ABSTRACT Objective and Design The growing demand for transparency about the efficacy of healthcare has accelerated the use of Patient‐Reported Outcome Measures (PROMs), but their integration into daily practice is challenging. This observational study describes how the Septoplasty Healthcare Monitor (SHM) addresses these challenges and highlights the ...
Victor S. van Dam, Diako Berzenji, Floris V. W. J. van Zijl, Martijn A. H. Oude Voshaar, Bernd Kremer, Frank R. Datema   +5 more
wiley   +1 more source

Platelet‐Rich Fibrin Can Improve Septoplasty Results: A Prospective Randomised Controlled Trial

Clinical Otolaryngology, EarlyView.
ABSTRACT Aim This study aims to assess the impact of platelet‐rich fibrin (PRF) on nasal mucociliary clearance (NMC) time and post‐operative pain following septoplasty. Patients and Methods This trial was conducted involving patients who underwent septoplasty. Participants were randomly assigned to either a control group or a PRF group.
Emre Solguntekin, Sedat Çağlı, Kerem Kökoğlu, Emrah Gülmez   +3 more
wiley   +1 more source