Results 71 to 80 of about 22,731 (179)

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

open access: yesMedicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting   +1 more
wiley   +1 more source

Taking a Newer, Faster, Intranasal Route: A Narrative Review of Transitioning to a Less-Invasive Rescue Treatment for Seizure Clusters

open access: yesPatient Preference and Adherence
Jurriaan M Peters,1 Danielle A Becker,2 Sunita N Misra,3 Enrique Carrazana,3,4 Adrian L Rabinowicz3 1Department of Neurology, Harvard Medical School and Boston Children’s Hospital, Boston, MA, USA; 2Department of Neurology, The Ohio State University ...
Peters JM   +4 more
doaj  

In Vivo Effects of N,N‐Diethyl‐Meta‐Toluamide (DEET) Exposure on Sinonasal Epithelia in a Murine Model

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Environmental factors, including airborne toxicants, are thought to contribute to the pathogenesis of chronic rhinosinusitis, although the exact mechanism is not fully understood. The purpose of this pilot study is to assess the impact of pesticide, N,N‐diethyl‐meta‐toluamide (DEET), on the sinonasal epithelium using an in vivo murine model ...
Jivianne T. Lee   +4 more
wiley   +1 more source

Radiofrequency Ablation Versus Laser Neurolysis of the Posterior Nasal Nerve in Patients With Chronic Rhinitis

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To compare the clinical outcomes of radiofrequency ablation of the intraturbinate segment of the posterior nasal nerve (RAPN) alone versus combined RAPN with CO₂ laser posterior nasal nerve neurolysis (RPN3) in patients with chronic rhinitis refractory to medical therapy. Study Design Retrospective cohort study.
Chia‐Chen Lin   +5 more
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai   +6 more
wiley   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

open access: yesPhytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli   +4 more
wiley   +1 more source

A Review of Metal–Organic Framework (MOF) Based Active Food Packaging: Materials Selection, Cellulose Matrices Current Advances, Synthesis and Characterizations

open access: yesPackaging Technology and Science, EarlyView.
Active packaging offers an effective approach to extending food shelf life. This review summarizes the past decade of progress in metal‐organic framework (MOF)‐based active food packaging, highlighting material selection, characterization, challenges, and future prospects.
Belladini Lovely   +4 more
wiley   +1 more source

Tailorable Curie Temperature in Zinc Ferrite Nanoparticles With Finely Tunable Induction Heating Profiles Between Room Temperature and 250°C

open access: yesSmall, EarlyView.
A spray‐drying‐based synthesis enables the formation of zinc ferrite nanoparticles with customizable induction heating from room temperature to 250°C by varying the zinc content and postsynthesis annealing temperatures. The aqueous dispersions are colloidally stable and heat up to biologically relevant thresholds. Hence, this approach offers a scalable
Leoni Luthardt   +7 more
wiley   +1 more source

Evaluation of the duration of new nasal drug interferon α-2b activity in an experimental model system

open access: yesVirology Journal
This study aimed To develop an adequate system for assessing the duration of IFN antiviral activity in the nasal cavity of animals and to study the antiviral activity of a new IFN drug in the form of a gel in comparison with the known spray form. Methods
N. Bezdieniezhnykh   +4 more
doaj   +1 more source

Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions.

open access: yesPLoS ONE, 2019
Deposition of polydisperse particles representing nasal spray application in a human nasal cavity was performed under transient breathing profiles of sniffing, constant flow, and breath hold. The LES turbulence model was used to describe the fluid phase.
Hadrien Calmet   +5 more
doaj   +1 more source

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