Results 181 to 190 of about 6,423 (263)

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

A retrospective study comparing the outcomes and toxicities of intensity-modulated radiotherapy versus two-dimensional conventional radiotherapy for the treatment of children and adolescent nasopharyngeal carcinoma [PDF]

, 2017

core   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Oral Health—Head and Neck Cancers: Addressing Confounding Through Negative Control and Quantitative Bias Analyses

Community Dentistry and Oral Epidemiology, Volume 54, Issue 3, Page 347-353, June 2026.
ABSTRACT Objectives While there are plausible biological explanations for the association between oral health and head and neck cancers (HNC), existing studies have yielded conflicting results. A key concern is that these associations are influenced by mediators, unmeasured risk factors, and biases. To address this, a negative control exposure was used
P. K. Elango, B. Nicolau, N. Farsi, A. V. Grant, M. C. Rousseau, S. Madathil   +5 more
wiley   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source

Predictive value of primary gross tumor volume measured by MRI in response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Background Neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally advanced rectal cancer (LARC), yet individual tumor regression response varies considerably. Purpose This study aimed to identify clinical factors linked to tumor regression grade (TRG) after nCRT in LARC and to evaluate MRI‐measured primary gross tumor volume (
Junbiao Li, Yuduo Wu, Shaoping Ye, Cuiying Fan, Yanping Lin, Dianhua Yang, Xiaoyi Xia, Yajing Kang, Dehao Liu, Junxin Wu   +9 more
wiley   +1 more source

Test‐time adaptation‐driven patient‐specific auto‐segmentation for CBCT‐guided online adaptive radiotherapy in cervical cancer

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Abstract Background Online adaptive radiotherapy using cone beam computed tomography (CBCT) of the pelvis can account for anatomical variations during cervical cancer treatment. However, the limitations of CBCT and existing auto‐segmentation methods, such as deformable image registration (DIR), hinder contouring and dosimetric accuracy.
Zhiqun Wang, Wei Zhang, Xiangyin Meng, Yongguang Liang, Tingting Dong, Jie Zhang, Nan Liu, Lang Yu, Bo Yang, Qichao Zhou, Jie Qiu   +10 more
wiley   +1 more source

A concept of equivalent‐volume concordance coefficient for comparing target volumes in radiotherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 5, May 2026.
Background The significant limitation of simple volume analyses for target volumes is that they disregard the spatial distribution of non‐overlapping volumes and the surrounding dose gradient. Purpose To present a concept of equivalent‐volume concordance coefficient (CCEV) for comparing target volumes in radiotherapy, which takes into account the dose ...
Xue Ou, Xianfei Qin, Huaye Wei, Lianrong Zheng, Di Huang, Qiulu Zhong, Kai Hu, Qinghua Du   +7 more
wiley   +1 more source

Association of plasma biomarkers with amyloid and tau PET in pre‐dementia stages

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Measuring plasma biomarkers effectively assesses early‐stage Alzheimer's disease. METHODS Subjects were categorized as cognitively unimpaired (CU) (n = 66), CU with subjective cognitive decline (SCD) (n = 100), and mild cognitive impairment (MCI) (n = 25).
Allal Boutajangout, Arjun V. Masurkar, Ricardo Osorio, Ludovic Debure, Mobeena Ghuman, Wajiha Ahmed, Alok Vedvyas, Elizabeth Pirraglia, Jon Links, Louisa Bokacheva, Brianna Vega, Mark A. Bernard, Karyn Marsh, Omonigho M Bubu, Yongzhao Shao, Joshua Chodosh, Henry Rusinek, Thomas Wisniewski   +17 more
wiley   +1 more source