Results 101 to 110 of about 347,220 (293)

Who We Are Is What Makes Us Laugh: Humour as Discourse on Identity and Hegemony

open access: yesInterlitteraria, 2019
There exists a sociocultural function to humour that is geared towards maintaining order through a subversion (or inversion) of the more serious, structured status quo, and while there is a pragmatic side to the dispensation of humour across any given ...
Christian Ylagan
doaj   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

open access: yesAdvanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin   +12 more
wiley   +1 more source

A Better Way to Generate and Use Comparative-Effectiveness Research [PDF]

open access: yes, 2009
President Barack Obama, former U.S. Senate majority leader Tom Daschle, and others propose a new government agency that would evaluate the relative effectiveness of medical treatments. The need for "comparative-effectiveness research" is great.
Michael F. Cannon
core  

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

open access: yesAdvanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu   +6 more
wiley   +1 more source

Mário de Andrade, the Other Way Around: Popular Music and "National Unconsciousness"

open access: yesEl Oído Pensante, 2016
In 1928, in his Ensaio sobre a Música Brasileira, Mário de Andrade lays the grounds for the creation of a nationalist school of music composition, arguing for the incorporation and elaboration of Brazilian popular music –its folklore, or rural music, as ...
Paula de Queiroz Carvalho Zimbres
doaj  

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

open access: yesAdvanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai   +6 more
wiley   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

open access: yesAdvanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies   +14 more
wiley   +1 more source

Antonio Gramsci and Paulo Freire : some connections and contrasts [PDF]

open access: yes, 2005
Antonio Gramsci (1891-1937) and Paulo Freire (1921-1997) are certainly two of the most cited figures in the debate concerning critical approaches to education.
Mayo, Peter
core  

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

open access: yesAdvanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu   +12 more
wiley   +1 more source

The Popular on British Television: Global Perspectives, National Priorities, Local Preferences

open access: yesCultura, Lenguaje y Representación, 2010
This article explores two related and highly significant aspects of British broadcasting: how the nature and identity of British television have been influenced by the potentially contradictory demands of high and low culture and associated popular and ...
Renée Dickason
doaj  

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