A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang +5 more
wiley +1 more source
Insights from the WHO Tricycle-aligned Fleming Fund EQASIA External Quality Assessment (EQA) programme detecting ESBL-, AmpC- and carbapenemase-producing Escherichia coli in South and South-East Asia. [PDF]
Al-Mir H +20 more
europepmc +1 more source
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song +9 more
wiley +1 more source
Description of the geographic distribution of excessive drinking across regional cultures in the United States: Framing an important health metric according to the cultural context of the American nations. [PDF]
Phillips SA +3 more
europepmc +1 more source
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
International Mentorship and Lifelong Learning in Plastic Surgery. [PDF]
Tremp M.
europepmc +1 more source
An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li +11 more
wiley +1 more source
EXPLORING THE SPATIALIZATION OF CULTURE: PERSPECTIVES FROM SLOVENIAN ETHNOLOGY
The article presents observations on the intricate processes of localizing peoples and cultures, drawing on their spatial mapping, a practice known since antiquity.
Ingrid Slavec Gradišnik
doaj
A 5-year review of <i>Helicobacter pylori</i> isolated from gastric biopsies at the UK Health Security Agency Gastrointestinal Bacteria Reference Unit. [PDF]
Swift C +5 more
europepmc +1 more source

