Results 121 to 130 of about 2,399,751 (353)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Psychological wellbeing, satisfaction with life and optimism in sports managers [PDF]
, 2015 In the discourse of its managers, the competitiveness of national sport is increasingly relative, or captive, to the constraints of competitiveness of the respective national economy with an obvious impact on productivity of sports associations and ...
Gonzaga, Luís +2 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Opera slavica, 2015 This article analyzes the features of perception and reflection of the Russian national character in the works of Nikolaj Leskov. The author the most completely considers the story, "Paddock", which is reflected in a concentrated form of Russian society ...
Ol'ga Vadimovna Stukalova
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Opera slavica, 2016 This article analyzes the features of perception and reflection of the Russian national character in the works of Nikolaj Leskov. The author conciders the most complete story, "Paddock", which is reflected in a concentrated form of Russian society in all
Ol'ga Vadimovna Stukalova
doaj
Creating Dissonance for the Visitor : The Heart of the Liberty Bell Controversy
, 2004 This paper examines the controversy surrounding the location and proposed interpretive plan for Independence National Historical Park\u27s new pavilion for the Liberty Bell.
Titus, Jill Ogline
core
Pembelajaran Bahasa Indonesia Berbasis Karakter Bangsa Pada Siswa Smk Negeri 2 Tabanan [PDF]
, 2013 This research used a qualitative descriptive design that aims to describe and explain (1) lesson planning, (2) the implementation of learning, and (3) evaluation of learning based on national character education in SMK Negeri 2 Tabanan.The subject of ...
Putrayasa, I. B. (I) +2 more
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source