Results 51 to 60 of about 29,787,584 (247)
Clinical Epidemiology, 2022 Natsuko Kanazawa,1,* Takuaki Tani,1,* Shinobu Imai,1– 3 Hiromasa Horiguchi,1 Kiyohide Fushimi,1,2 Norihiko Inoue1,2 1Department of Clinical Data Management and Research, Clinical Research Center, National Hospital Organization Headquarters, Tokyo,
Kanazawa N +5 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Irish Hip Fracture Database National Report 2017 [PDF]
, 2018 This report is testament to the commitment of all the participating hospitals to the Irish Hip Fracture Database (IHFD) and the focus on providing hip fracture patients with care that is aligned to international best practice standards. The report also
National Office of Clinical Audit
core
Irish Hip Fracture Database summary report 2020
, 2022 The Irish Hip Fracture Database (IHFD) was set up to measure the care for all patients over the age of 60 who suffer a hip fracture. There are 16 hospitals who operate on hip fracture patients.
The National Office of Clinical Audit (NOCA) (11202798) +1 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Sepsis Management for Adults (including maternity): National Clinical Guideline No. 26
, 2021 This National Clinical Guideline (NCG), has been developed by the Sepsis Guideline Development Group (GDG), within the HSE National Sepsis Programme (NSP). The National Clinical Effectiveness Committee (NCEC) was requested by the Minister for Health to
Sepsis Guideline Development Group +1 more
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BMC Health Services Research, 2018 Background Swedish National Quality Registries (NQRs) are observational clinical registries that have long been seen as an underused resource for research and quality improvement (QI) in health care.
Vibeke Sparring +4 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source