Results 191 to 200 of about 410,655 (264)

Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis

Advanced Science, EarlyView.
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim, Ha Kyeong Lee, Zulfikar Azam, Jeong Uk Choi, Riajul Wahab, Na Kyeong Lee, Yoon Gun Ko, So‐Young Choi, Se‐Ra Lee, Wan Seob Shim, Taeeung Kim, In‐San Kim, Farzana Alam, Sang Yoon Kim, Seong Who Kim, Youngro Byun, Taslim A Al‐Hilal   +16 more
wiley   +1 more source

Computational pathology features of immune architecture predict clinically relevant outcomes in small-cell lung cancer (SCLC). [PDF]

NPJ Precis Oncol
Barrera C, Jain P, Corredor G, Dam T, Maurya H, Pathak T, Beshai B, Perimbeti S, Jagirdar J, Higgins K, Dowlati A, Madabhushi A.   +11 more
europepmc   +1 more source

Divergent Regulatory Effects of Jasmonic Acid on Tomato Lycopene Biosynthesis Under Light and Dark Conditions

Advanced Science, EarlyView.
This study reveals the mechanism by which jasmonic acid (JA) regulates lycopene synthesis under light and dark conditions. In light, JA activates SlMYC2, which suppresses SlPIF1a and promotes SlPSY1 expression. In darkness, JA induces the acetyltransferase SlNATA1, which acetylates the dark‐accumulated SlPIF1a, thereby repressing SlPSY1 expression ...
Jiayi Xu, Lingfeng He, Jialong Zhang, Hao Cui, Hongxin Li, Haijun Zhang, Jiaojiao Zhang, Lun Liu, Kunpeng Xu, Yang‐Dong Guo, Na Zhang   +10 more
wiley   +1 more source

A Case of Myxoid Glioneuronal Tumor in the Lateral Ventricle. [PDF]

NMC Case Rep J
Ueki W, Toyooka T, Kuboshima K, Yamamoto T, Fujii K, Takeuchi S, Tomiyama A, Kumazawa F, Sato K, Yokoo H, Wada K.   +10 more
europepmc   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Ecological determinants of altruism in prokaryote antivirus defense. [PDF]

Biol Direct
Biba DA, Makarova KS, Wolf YI, Waldron L, Koonin EV, Rochman ND.   +5 more
europepmc   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Correction: Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications. [PDF]

Biomater Sci
Khalil IA, Saleh B, Ibrahim DM, Jumelle C, Yung A, Dana R, Annabi N.   +6 more
europepmc   +1 more source

Reply to Dujmović: The alignment in cost between human and model reasoning is an empirical phenomenon worth explaining. [PDF]

Proc Natl Acad Sci U S A
de Varda AG, D'Elia FP, Kean H, Lampinen A, Fedorenko E.   +4 more
europepmc   +1 more source

Regulation-Focused Psychotherapy for Children With Emotion Dysregulation. [PDF]

J Korean Acad Child Adolesc Psychiatry
Maeng S, Kim YS, Moon DS.
europepmc   +1 more source