Results 31 to 40 of about 410,655 (264)
Revista de Administração Pública, 2007 As transformações sofridas pelo Estado brasileiro têm sido parte integrante do debate político e acadêmico do país desde o período da redemocratização na década de 1980.
Octavio Penna Pieranti +2 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
STRATEGIC DEFENSE – A MODERN APPROACH TO NATIONAL DEFENSE STRATEGY [PDF]
Annals: Series on Military Sciences, 2021 From the Cold War period until now, several strategies for carrying out wars have emerged, culminating in the "Hybrid War" model. This literature study is a modern approach to strategic defense and brings to the forefront a series of reflective ...
Captain (N) Professor Sorin TOPOR, PhD
doaj
Climate change and national defense [PDF]
Војно дело, 2015 Climate change, as one of the greatest challenges facing the contemporary society, continues to attract the attention of both political and scientific community for a rather long time.
Cvetković Vladimir M. +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Evolution of French Military Policy
Вестник Кемеровского государственного университета. Серия: политические, социологические и экономические науки, 2023 The article studies the evolution of the military-political course of the French Fifth Republic. The authors provide a comprehensive analysis of the four editions of the French White Paper, which are the conceptual foundations of the country’s defense ...
Olga A. Smirnova, Milena V. Shpigovskaya
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Future Direction of Korean Defense Policy
선진국방연구, 2020 The article is organized as follows. The first clarifies research questions, the purpose of study and methodology about Ori’s national defense policy analysis. Japanese invasion of Korea happened in 1952(壬辰倭亂) & 1597(丁酉再亂).
Jongsoo Lee
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source