Results 41 to 50 of about 24,269,187 (198)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Comparing the predictive power of the National Early Warning Score (NEWS) and Modified Early Warning Score (MEWS) for ICU admission in respiratory patients during the COVID-19 pandemic: A multicenter cross-sectional study

International Journal of Emergency Medicine
Background Early identification of clinical deterioration in respiratory patients is essential for timely intervention and ICU admission in emergency departments.
Marzieh Barati Golsheikhi, Zahra Rooddehghan, Maryam Esmaeili, Raoofeh Karimi   +3 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

External validation of the International Early Warning Score in non-traumatic emergency department patients: a prospective cohort study

BMC Emergency Medicine
Background Emergency department (ED) overcrowding has become a global public health concern, underscoring the importance of rapid and reliable risk stratification tools.
Fatma Bayram, Buğra İlhan, Zeynep Kan, Oğuz Eroğlu, Turgut Deniz   +4 more
doaj   +1 more source

National early warning score pisteytyksen avulla tehtävä hoidon tarpeen arviointi kotihoidossa [PDF]

, 2021
National early warning score -järjestelmä on kehitetty Iso-Britannialaisen hyväntekeväisyysjärjestön ja Royal College of Physicians asiantuntijaorganisaation toimesta vuonna 2012.
Karvonen, Karoliina, Kokkonen, Katja
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Abbreviated National Early Warning Score predicts the need for hospital admission and in-hospital mortality in elderly patients

Emergency Care Journal, 2018
The aim of this study was to evaluate the value of the Abbreviated National Early Warning Score (aNEWS) for predicting admissions and in-hospital mortality in elderly patients present to Emergency Department (ED).
Toshiya Mitsunaga, Masahiko Hujita, Izumu Hasegawa, Kei Otani, Kenji Okuno, Yuhei Ohtaki, Yutaka Seki, Kunihiro Mashiko, Satoshi Takeda   +8 more
doaj   +1 more source

Prediction of In-Hospital Cardiac Arrest Using Shallow and Deep Learning

Diagnostics, 2021
Sudden cardiac arrest can leave serious brain damage or lead to death, so it is very important to predict before a cardiac arrest occurs. However, early warning score systems including the National Early Warning Score, are associated with low sensitivity
Minsu Chae, Sangwook Han, Hyowook Gil, Namjun Cho, Hwamin Lee   +4 more
doaj   +1 more source

Budget Impact Analysis – The National Early Warning System (NEWS)

, 2020
There are two key components for evaluating the economic impact of a new intervention: (1) a cost-effectiveness analysis, which estimates the incremental costs and benefits of the new intervention compared with the current standard of care for the ...
Health Information and Quality Authority (HIQA)
core