Results 31 to 40 of about 322,775 (269)

Mastering your fellowship: Part 1, 2025

South African Family Practice
The series ‘Mastering your Fellowship’ provides examples of the question formats encountered in the written and clinical examinations, Part A of the Fellowship of the College of Family Physicians of South Africa (FCFP [SA]) examination.
Klaus B. von Pressentin, John M. Musonda, Mergan Naidoo, Michéle Torlutter, Gert Marincowitz, Selvandran Rangiah, Zakariya Badat   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mastering your Fellowship: Part 2, 2025

South African Family Practice
The ‘Mastering your Fellowship’ series provides examples of the question format encountered in the written and clinical examinations for the Fellowship of the College of Family Physicians of South Africa (FCFP [SA]) examination.
Mergan Naidoo, Klaus von Pressentin, John M. Musonda, Selvandran Rangiah, Chantelle van der Bijl   +4 more
doaj   +1 more source

The impact of an intervention to introduce malaria rapid diagnostic tests on fever case management in a high transmission setting in Uganda: A mixed-methods cluster-randomized trial (PRIME). [PDF]

, 2017
Rapid diagnostic tests for malaria (mRDTs) have been scaled-up widely across Africa. The PRIME study evaluated an intervention aiming to improve fever case management using mRDTs at public health centers in Uganda.
A Namagembe, AK Mbonye, B Cundill, Catherine Maiteki-Sebuguzi, Christine Nabirye, CI Chandler, Clare I. R. Chandler, David Joseph Diemert, DD DiLiberto, Deborah D. DiLiberto, DH Hamer, DJ Kyabayinze, DJ Kyabayinze, Emily L. Webb, Emmanuel Ssemmondo, Grant Dorsey, H Hildenwall, H Reyburn, J Biehl, J Skarbinski, JI Nankabirwa, K Bruxvoort, K Elfving, M Kilama, ME Rafael, Moses R. Kamya, P Mbabazi, RJ Hayes, Sarah G. Staedke, SG Staedke, SG Staedke, Susan Nayiga, U Ssekabira, V D'Acremont, WF Mbacham, Y Lubell, Z Bisoffi   +36 more
core   +4 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mastering your fellowship: Part 4, 2025

South African Family Practice
The ‘Mastering your Fellowship’ series provides examples of the question format encountered in the written and clinical examinations for the Fellowship of the College of Family Physicians of South Africa (FCFP [SA]) examination.
Mergan Naidoo, Klaus Von Pressentin, John M. Musonda, Selvandran Rangiah, Michele Torlutter, Joyce S. Musonda   +5 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Training family physicians: A qualitative exploration of experiences of registrars in a family medicine training programme in Cape Town, South Africa

South African Family Practice, 2020
Background: The MMed in Family Medicine is a professional Master’s qualification spanning 4 years of training. The outcomes were predetermined by national consensus.
Tasleem Ras, Beverley Schweitzer, Graham Bresick, Derek Hellenberg   +3 more
doaj   +1 more source

Innovation and venture capital exit performance [PDF]

, 2011
Venture capital is a potent source of R&D financing which contributes significantly to technological innovation output in the form of patented inventions.
Acs, Admati, Amit, Archibugi, Arrow, Barney, Bascha, Baum, Brouwer, Cantwell, Chemmanur, Clarysse, Cochrane, Cumming, Das, Economist Intelligence, European Commission DR, Geroski, Giot, Global Insight, Gompers, Gompers, Gompers, Gompers, Granstrand, Granstrand, Grant, Griliches, Griliches, Guler, Hall, Hege, Hitt, Huyghebaert, Kaplan, Kortum, Kortum, Laperche, Makri, Mann, Metrick, Murray, Nadeau, Narin, O'Sullivan, Penrose, Porter, Porter, Priem, Romer, Romer, Spender, Stuck, Thornhill, Wernerfelt, Woodward, Zingales   +56 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source