Results 71 to 80 of about 322,775 (269)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Labour efficiency on-farm [PDF]

, 2007
End of project reportImprovements in milking efficiency have a greater influence than any other aspect of the dairy farmers work on overall farm labour inputs (Whipp, 1992).
Boyle, Laura, Gleeson, David E, Kinsella, J., McNamara, John G., Mee, John F, O'Brien, Bernadette, O'Donovan, K., Ruane, D.   +7 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Mastering your fellowship: Part 2, 2024

South African Family Practice
The ‘Mastering your Fellowship’ series provides examples of the question format encountered in the written and clinical examinations, Part A of the Fellowship of the College of Family Physicians of South Africa (FCFP [SA]) examination.
Mergan Naidoo, Klaus von Pressentin, Andrew Ross, Selvandran Rangiah   +3 more
doaj   +1 more source

Nursing education and regulation: international profiles and perspectives

, 2007
This review of nurse education and regulation in selected OECD countries forms part of ongoing work on contemporary nursing careers and working lives, based at the National Nursing Research Unit, King’s College London.
Griffiths, Peter, Robinson, Sarah
core  

Science Leadership: Impact of the New Science Coordinators Academy [PDF]

, 2015
This article discusses the impact of the New Science Coordinators Academy (NSCA) on two cohorts of participants. The NSCA is one of four components of the Virginia Initiative for Science Teaching and Achievement (VISTA), a United States Department of ...
Edmondson, E. W., Mannarino, A., Reid, V., Sterling, D. R.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

An Analysis of the "Promotion or Exit" System for University Teachers: From the Perspective of Procedural Justice Theory

Jiaoshi jiaoyu xuebao
One of the core purposes of introducing the "Promotion or Exit" system in Chinese universities is to create a fair and just competition order for the profession of teachers, with procedural justice as its inherent function and the starting point for the ...
FAN Qi
doaj   +1 more source

Improving the quality of clinical training in the workplace: implementing formative assessment visits

South African Family Practice, 2019
Family physicians have a key role to play in strengthening district health services in South Africa. There are a number of barriers to the supply of these specialists in family medicine, one of which is the quality of workplace-based training and low ...
Robert Mash, Zelra Malan, Julia Blitz, Jill Edwards   +3 more
doaj   +1 more source

Experience of implantation of flow-diverter in the acute period of aneurismatic intracranial hemorrhage

Ендоваскулярна нейрорентгенохірургія, 2020
In the period from 2013 to 2019 at the Scientific and Practical Center for Endovascular Neuroradiology of the National Academy of Medical Sciences of Ukraine, implantation of flow-diverter in the acute period of aneurysmal intracranial hemorrhage was ...
D.V. Shchehlov, O.A. Pastushyn, O.E. Svyrydiuk, S.V. Konotopchik, A.V. Naida   +4 more
doaj   +1 more source