Results 111 to 120 of about 2,122,223 (291)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Association between Tobacco Use and Hypertension among Women of Prime Childbearing Age (20–34 Years) in India: Insights from National Family Health Survey-5 Data

Indian Journal of Public Health
Background: Hypertension and tobacco use are significant public health concerns with detrimental effects during pregnancy. Objectives: This study was conducted to assess the association between tobacco use and hypertension among women of prime ...
S. Rahini, Sonika Raj, Piyasa Mal, Madhu Gupta, Sonu Goel   +4 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A comparative study of National Family Health Survey-4 and National Family Health Survey-5 on quality of family planning services and unmet need for family planning indicators in Assam

International Journal Of Community Medicine And Public Health
Family planning is an important component of health, welfare, family stability as well as the social and economic progress of a community. The purpose of this study is to assess the shifts in the quality of family planning services and unmet needs in Assam based on National Family Health Survey (NFHS) rounds 4 and 5.
Ashfia Habib, Sthapana Sharma, Aamir Saeed, Achyut C. Bhaisya, Jutika Ojah   +4 more
openaire   +1 more source

Epidemiology, prevention and control of oral diseases in pediatric subjects [PDF]

, 2019
Caries and periodontal diseases are a neglected epidemic by millions of Italians who suffer unnecessarily from them. Both diseases are preventable and the combination of high prevalence, high morbidity and relative inattention from the National Health
Buttacavoli F., Giuliana G, Maltese A. M., Pizzo G.   +3 more
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Spatial Proximity and Contacts between Elderly Parents and Their Adult Children: A European Comparison [PDF]

Using data from the 2004 'Survey of Health, Ageing and Retirement in Europe' (SHARE), this paper continues and extends recent cross-national research on the proximity and contacts of elderly parents to their adult children.
Karsten Hank
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Behind closed doors: national survey insights on sexual violence among ever-married women in India

Discover Public Health
This study aims to assess the prevalence and determinants of sexual violence among married women in India using data from the National Family Health Survey-5 (NFHS-5) and the risk factors influencing it.
Deepthi Ramamurthy, Ashwini Lonimath, Suthanthira Kannan, Mohammed Shoyaib Khazi   +3 more
doaj   +1 more source