Results 61 to 70 of about 1,312,903 (305)

X-ray inactivation of RNA viruses without loss of biological characteristics

Scientific Reports, 2020
In the event of an unpredictable viral outbreak requiring high/maximum biosafety containment facilities (i.e. BSL3 and BSL4), X-ray irradiation has the potential to relieve pressures on conventional diagnostic bottlenecks and expediate work at lower ...
Babak Afrough, Jonathan Eakins, Sarah Durley-White, Stuart Dowall, Stephen Findlay-Wilson, Victoria Graham, Kuiama Lewandowski, Daniel P. Carter, Roger Hewson   +8 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The integrated approach in primary care during COVID-19 era: Are we missing our chance?

Advances in Biomedical and Health Sciences
The ongoing economic crisis, the numerous wars, and the coronavirus disease (COVID-19) pandemic have burdened various healthcare systems worldwide, hindering care equity and doctor–patient relationships.
Valerio Massimo Magro
doaj   +1 more source

Prospective observational cohort study of ‘treatment as usual’ over four years for patients with schizophrenia in a national forensic hospital

BMC Psychiatry, 2018
Background We evaluated change in response to multi-modal psychosocial ‘treatment as usual’ programs offered within a forensic hospital. Methods Sixty nine patients with a diagnosis of schizophrenia or schizoaffective disorder were followed for up to ...
Melanie S. Richter, Ken O’Reilly, Danny O’Sullivan, Padraic O’Flynn, Aiden Corvin, Gary Donohoe, Ciaran Coyle, Mary Davoren, Caroline Higgins, Orla Byrne, Tina Nutley, Andrea Nulty, Kapil Sharma, Paul O’Connell, Harry G. Kennedy   +14 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

External quality assessment of national public health laboratories in Africa, 2002-2009

Bulletin of the World Health Organization, 2012
OBJECTIVE: To describe findings from an external quality assessment programme involving laboratories in Africa that routinely investigate epidemic-prone diseases. METHODS: Beginning in 2002, the Regional Office for Africa of the World Health Organization
John Frean, Olga Perovic, Vivian Fensham, Kerrigan McCarthy, Anne von Gottberg, Linda de Gouveia, Bhavani Poonsamy, Leigh Dini, Jenny Rossouw, Karen Keddy, Wondimagegnehu Alemu, Ali Yahaya, Antoine Pierson, Virginie Dolmazon, Sébastien Cognat, Jean Bosco Ndihokubwayo   +15 more
doaj  

International health data reference guide [PDF]

, 1983
NCHS.Title from caption.Vols. for 1983-1987 issued as DHHS publication.Vol. for 1985 published by the Office of International Statistics, National Center for Health Statistics; 1987 by the International Statistics Staff, Office of Planning and Extramural
National Center for Health Statistics (U.S.) Office of International Statistics.
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Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Mental health statistics.

, 1969
No. 1-5 issued as Public Health Service publication, no. 1860, etc.; no. 6-12 issued as DHEW publication no.
National Institute of Mental Health (U.S.), National Clearinghouse for Mental Health Information.   +1 more
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