Results 211 to 220 of about 34,996,239 (300)

Evidence speaks beyond conceptual frameworks

The Lancet Regional Health. Americas
Mariana Álvarez-Aceves, Lina Sofía Palacio-Mejía, Mauricio Hernández-Ávila, Edgar Leonel González-González, Carlos Arturo Castro-Del Ángel, Leslie Guzmán-Sandoval, Juan Eugenio Hernández-Ávila   +6 more
doaj   +1 more source

Intersecting inequalities in experiences of violence among Brazilian adults: a multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) of the 2019 National Health Survey. [PDF]

Int J Equity Health
Hammett WH, Macinko J.
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Central obesity and its association with youth physical and mental health: evidence from the Australian National Health Survey. [PDF]

BMC Med
Aychiluhm SB, Ross AG, Isaac V, Thapa S, Ahmed KY.   +4 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Diet and Lifestyle Factors Associated with Gastrointestinal Symptoms in Spanish Adults: Cross-Sectional Analysis of the 2023 Spanish National Health Survey. [PDF]

Nutrients
López-Fernández-Roldán Á, Serrano-Fernández V, Laredo-Aguilera JA, Barroso-Corroto E, De Paz-Montón LP, Carmona-Torres JM.   +5 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Diabetes Mellitus screening and associated factors in Peru: A cross-sectional analysis of a national health survey. [PDF]

PLOS Glob Public Health
Arevalo-Rios ECE, Layza-Reyes J, Noriega-Ruiz VH.   +2 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source