Results 121 to 130 of about 27,553,759 (265)
Excerpt, Oral History Interview, Harry Kitano
, 1986 Excerpt, summary, and index of an oral history interview of Harry Kitano. Conducted by Eric Saul on July 12, 1986, in San Francisco, CA. Transcriber unknown. Edited by Yi-Shen Loo.This oral history interview was conducted for the MIS Oral History Project
Harry Kitano, Eric Saul
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Excerpt, Oral History Interview, William Nosaka
, 1986 Excerpt, summary, and index of an oral history interview of William Nosaka. Conducted by Eric Saul on March 23, 1986, in San Francisco, CA. Transcribed by Yi-Shen Loo.This oral history interview was conducted for the MIS Oral History Project by the ...
William Nosaka, Eric Saul
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Excerpt, Oral History Interview, Ryo Mishima
, 1993 Excerpt, summary, and index of an oral history interview of Ryo Mishima. Conducted by Chizu Iiyama, Lisa Hirai, and Mr. Nishimura on December 3, 1993. Transcribed by Charlene Tonai Din.This oral history interview was conducted for the MIS Oral History ...
Chizu Iiyama, Lisa Hirai, Mr. Nishimura +1 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Excerpt, Oral History Interview, Toyo Suyemoto
, 1993 Excerpt, summary, and index of an oral history interview of Toyo Suyemoto. Conducted by Chizu Iiyama on August 9, 1993, in Columbus, OH. Transcribed by Malia Ema Okamura.This oral history interview was conducted for the MIS Oral History Project by the ...
Toyo Suyemoto, Chizu Iiyama
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Excerpt, Oral History Interview, Lily Sasaki
, 1990 Excerpt, summary, and index of an oral history interview of Lily Sasaki. Conducted by Chizu Iiyama on April 17, 1990, in Berkeley, CA. Transcribed by Yi-Shen Loo.This oral history interview was conducted for the MIS Oral History Project by the Military ...
Lily Sasaki, Chizu Iiyama
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