Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
DO THE HUMOUR SKILLS OF AN EMPLOYEE HELP? ROLE OF EMOTIONAL EXHAUSTION AT THE WORKPLACE
The research analyzes the effect of Psychological Contract Breach (PCB) on Organization Citizenship Behavior (OCB) with the help of Emotional Exhaustion (EE) taken as a mediating variable.
Uzair Shahid, Syeda Nida Ali Zaidi
doaj
La leadership politica in Italia alla luce della tradizione comica nazionale
Political leadership in Italy in the light of the national comical traditionThis essay deals with humour and satire in politics. The issue of humour is contextualized within a wider cultural phenomenon called ‘show civilisation’ or ‘schermopolis’, i.e ...
Maria Pia Pozzato
doaj +1 more source
L’écriture en crise pour un pays en crise. "Alger, journal intense" de Mustapha Benfodil
Depuis son roman Archéologie du chaos (amoureux) paru en 2007, Mustapha Benfodil s’applique à mettre en œuvre le programme énoncé par l’un de ses personnages : DECONSTRUIRE L’ORDRE NARRATIF NATIONAL.
Sylvie Brodziak
doaj +1 more source
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
Terror i tvillingtårnene – dystopi og ironi? 9/11 i Darlah og En terrorist i senga
Terror in the Twin Towers – dystopia and irony? 9/11 in Darlah and En terrorist i senga. Through globalization of our media society, children as well as adults are endlessly exposed to information and images from all over the world.
Kjersti Lersbryggen Mørk
doaj +1 more source
Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan +14 more
wiley +1 more source
Trevor Noah and the contingent politics of racial joking
This article takes up the transnational comedy career of Trevor Noah as a way to explore how the political work of racial comedy can manifest, circulate and indeed communicate differently across different racial-political contexts.
Jennalee Donian, Nicholas Holm
doaj +1 more source
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao +5 more
wiley +1 more source
The language of humour: the humour of language irony and humour in interpersonal verbal encounters
In this paper the problem of verbal humour and irony is approached from a sociolinguistic perspective, starting from the Semantic Script Theory of Humour (Raskin 1985), which establishes that all humour involves a semantic-pragmatic process.
Zsuzsanna Ajtony
doaj

