Results 101 to 110 of about 24,111,558 (299)

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Participatory development of Indonesia’s national action plan for zero leprosy: strategies and interventions

Frontiers in Public Health
RationaleLeprosy remains a significant public health problem in Indonesia, with 14,000–15,000 new cases reported each year, indicating ongoing transmission.
Perigrinus Hermin Sebong, Perigrinus Hermin Sebong, Astri Ferdiana, Astri Ferdiana, Florisma Arista Riti Tegu, Deni Harbianto, Ronny Soviandhi, Asken Sinaga, Teky Budiawan, Arnoldus Janssen Angga Yanuar Risnanto, Regina Tiolina Sidjabat, Trijoko Yudopuspito, Ridwan Mawardi, Eny Setyawati, Adi Utarini, Adi Utarini   +15 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

National Development Plan for the Period 1979-1983 Part II

, 1979
The development objectives, strategies and policies to guide the national development effort over this plan period are outlined in Part I of the 1979-83 Development Plan. Part II provides data on development programme and projects which the Government

core  

National Operational Plan 2013: Implementing the National Service Plan 2013

, 2013
This National Operational Plan has therefore been developed to support the implementation of NSP2013 by setting out a national position for each main care group / programme in order to guide the translation of national policy into the four Regional Service Plans and the three Hospital Group Plans: HSE Dublin Mid Leinster HSE Dublin North East HSE South
openaire   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Terms of reference for pilot projects to inform the implementation of the National Drugs Rehabilitation Framework

, 2010
Note: this document should be read be read in conjunction with the National Drugs Rehabilitation Framework Document (June 2010) and the Report of the Working Group on Drugs Rehabilitation (2007).The objectives of the pilot projects are to: • support the
National Drugs Rehabilitation Implementation Committee
core  

Kakamega Municipality Capital Investment Plan 2017-2020 [PDF]

, 2017
This Capital Investment Plan (CIP) seeks to provide practical guidance on the implementation of the capital development aspects within the Integrated Strategic Urban Development Plan (ISUDP) for Kakamega Municipality.

core  

National Artificial Intelligence Research and Development Strategic Plan: A Report by the Select Committee on Artificial Intelligence of the National Science and Technology Council

, 2023
"This document includes relevant text from the 2016 and 2019 national AI R&D strategic plans, along with updates prepared in 2023 based on Administration and interagency evaluation of the National AI R&D Strategic Plan: 2019 Update as well as community ...
National Science and Technology Council (U.S.). Select Committee on Artificial Intelligence.
core  

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source